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4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-(trideuteriomethyl)pyridine-2-carboxamide

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Origin: China

Cas No: 1130115-44-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 1130115-44-4 Formula: C21H13ClD3F3N4O3 Molecular Weight: 467.84300

Description

Labelled Sorafenib, a potent RAF kinase inhibitor. Antineoplastic.

Basic Info

Chemical Name	4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-(trideuteriomethyl)pyridine-2-carboxamide
Synonyms	SIMVASTATIN 4'-METHYL ETHER; Sorafenib-d3; BAY-43-9006-d3; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-phenyoxy)-N-(methyl-d3)picolinamide; Sorafenib D3; Sorafenib-methyl-d3; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-(methyl-d3)aminoformyl)-4-pyridyloxy)phenyl)urea; 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-(methyl-d3)-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-phenoxy)-N-(methyl-d3)picolinamide;
CAS No.	1130115-44-4
Molecular Formula	C21H13ClD3F3N4O3
Molecular Weight	467.84300
PSA	92.35000
LogP	6.08660

Synthesis Route

methyl 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxylate+trideuteriomethanamine,hydrochloride→4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-(trideuteriomethyl)pyridine-2-carboxamide
[4-(4-Aminophenoxy)(2-pyridyl)]-N-(methyl-d3)carboxamide+5-amino-2-chlorobenzotrifluoride→4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-(trideuteriomethyl)pyridine-2-carboxamide
[4-(4-Aminophenoxy)(2-pyridyl)]-N-(methyl-d3)carboxamide+4-Chloro-3-(trifluoromethyl)phenyl isocyanate→4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-(trideuteriomethyl)pyridine-2-carboxamide

Precursor

5-amino-2-chlorobenzotrifluoride
methyl 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]pyridine-2-carboxylate
N,N'-Carbonyldiimidazole
[4-(4-Aminophenoxy)(2-pyridyl)]-N-(methyl-d3)carboxamide

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