Home > Heterocyclic Compounds> (3R)-7-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid

(3R)-7-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid

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Origin: China

Cas No: 214630-00-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 214630-00-9 Formula: C15H19NO5 Molecular Weight: 293.31500

Description

Boc-7-Hydroxy-D-tic-OH is an intermediate used to prepare highly potent and selective opioid κ receptor antagonists.

Basic Info

Chemical Name	(3R)-7-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
Synonyms	(R)-7-Hydroxy-2-Boc-3,4-dihydro-isoquinoline-3-carboxylic acid; (R)-2-(tert-Butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; BOC-7-HYDROXY-D-TIC-OH; 7-OH-Boc-D-Tic; Boc-D-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; (3R)-2-(tert-butoxycarbonyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; 7-hydroxy-Boc-D-Tic; AmbotzBAA1462; Boc-D-Tic(OH)-OH;
CAS No.	214630-00-9
Molecular Formula	C15H19NO5
Molecular Weight	293.31500
PSA	87.07000
LogP	2.07650

Properties

Density	1.274g/cm3
Boiling Point	484.716ºC at 760 mmHg
Flash Point	246.948ºC
Refractive Index	1.561
Storage Condition	-15ºC

Safety Info

HS Code	2933499090

Synthesis Route

(3R)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid+tert-butoxycarbonyl anhydride→(3R)-7-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid

Precursor

tert-butoxycarbonyl anhydride
(3R)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Downstream Product

(3R)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
(3R)-7-hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide dihydrochloride

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