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Nicotinamide

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Origin: China

Cas No: 98-92-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 1000 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Standards USP, EP, BP, JP, ChP,  GB/T7301-2002, etc.

    It is also called Vitamin B3, Vitamin PP, white granular powder or white crystalline powder, odorless or almost odorless, bitter taste. It is mainly used in Vitamin medicine, food additive, feed additive, cosmetics additives. It can also be used for synthesis of other chemical products.

    [CHEMICAL NAME]  3-Pyridinecarboxamide

    [ENGLISH NAME]     Nicotinamide/Niacinamide

    [SYNONYM]               Vitamin B3,Vitamin PP

    [CAS#]                        98-92-0

    [MOLECULAR FORMULA AND WEIGHT] C6H6N2O=122.13

    [STRUCTURAL FORMULA]

     

    [CHARACTERISTICS]       White granular powder or white crystalline powder, odorless or almost odorless, 

                                                bitter taste

    [PHYSICAL PROPERTIES] Melting Point:128~131℃

                                                Boiling Point:150~160℃(0.07kPa)

                                                Flash Point:182℃

                                                Solubility:Soluble in water, ethanol, sodium carbonate solution, sodium 

                                                hydroxide solution, dissolving in glycerin, almost insoluble in ether

    [MAIN USES]                     Vitamin medicine, food additive, feed additive, cosmetics additives. It can also 

                                                be used for synthesis of other chemical products

    [PRODUCT GRADES]        Pharmaceutical Grade, Food Grade, Cosmetic Grade, Feed Grade

    [EXECUTIVE STANDARD] The products of our company comply with standards USP, EP, BP, JP, ChP, 

                                                GB/T7301-2002, etc.

    [PACKING]                         20KG/Carton, 20KG/Bag,25KG/Carton,1000Kg/Bag

    [STORAGE]                         Dry, cool, indoor storage

     

    The Nicotinamide of Redpont Biotech has the following characteristics:

    1. High starting point. 

    The production process is designed and constructed strictly according to GMP requirements. The product specifications include pharmaceutical grade, food grade, feed grade, cosmetic grade. The quality conforms to the the United States Pharmacopoeia(USP), the European Pharmacopoeia (EP), the British Pharmacopoeia(BP), the Japanese Pharmacopoeia(JP), the Chinese Pharmacopoeia, the Chinese feed standard GB/T7301-2002,etc.

     

    2. Advanced equipments and high degree automation. 

    The most advanced equipments have been used in the production, and the process is integrated controlled by the DCS, with continuous production, simple operation, fewer personnel, which greatly ensure the stability of product’s quality.

     

    3. High safety performance of the production process. 

    Strict security risk assessment of the whole production process has been made; The investment for links which may cause safety accidents has been increased to achieve one key to stop design, ensures safety production.

     

    4. Well-equipped facilities of energy saving and environmental protection. 

    The equipments have been increased to make use of the heat generated in the production process, to recycle the waste steam, which greatly saved energy. The waste water, waste gas and waste residue produced in the process have been discharged up to the standards.

     

    5.Strong awareness of food safety. 

    Besides strictly in accordance with the requirements of GMP management on production process, a set of product traceability system has been brought in. That is to say every unit (box or bag) product has an unique bar code identification, which can track all the situation during product’s manufacturing process. Customers can also use this bar code to carry on production management.

     

    6. Use robots to reduce labor intensity. 

    Humanized management has been taken on the production process. The robot operation has been used in the high intensity labor field, such as product’s transfering, stacking, which greatly protects the operators.

  •  

    Property

    CAS No.: 98-92-0 Formula: C6H6N2O Molecular Weight: 122.12500
     

    Description

    Nicotinamide, also known as niacinamide, NAA, and nicotinic amide, is the amide of nicotinic acid (vitamin B3 / niacin). Nicotinamide is a water-soluble vitamin and is part of the vitamin B group. Nicotinic acid, also known as niacin, is converted to nicotinamide in vivo, and, though the two are identical in their vitamin functions, nicotinamide does not have the same pharmacological and toxic effects of niacin, which occur incidental to niacin's conversion. Thus nicotinamide does not reduce cholesterol or cause flushing, although nicotinamide may be toxic to the liver at doses exceeding 3 g/day for adults. In cells, niacin is incorporated into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), although the pathways for nicotinic acid amide and nicotinic acid are very similar. NAD+ and NADP+ are coenzymes in a wide variety of enzymatic oxidation-reduction reactions. Commercial production of niacin and niacinamide (several thousand tons annually) is by hydrolysis or aminolysis of 3-cyanopyridine (nicotinonitrile).
    Small intestinal bacterial overgrowth is one known cause of nicotinamide deficiency.
     

    Basic Info

    Chemical Name Nicotinamide
    Synonyms

    Vitamin B3 (Nicotinamide);
    Vitamin PP (Nicotinamide);
    NAM;
    Pyridine-3-carboxamide;
    Nicotinic acid amide;
    3-Pyridinecarboxamide;
    Nicotinic amide;
    Niacinamide;

    CAS No. 98-92-0
    Molecular Formula C6H6N2O
    Molecular Weight 122.12500
    PSA 55.98000
    LogP 0.88080
     

    Properties

    Density 1.40 g/cm3
    Boiling Point 334 °C
    Melting Point 129.5 °C
    Flash Point 182 °C
    Refractive Index 1.4660 (estimate)
    Water Solubility Soluble, 691g/L (20°C)
     

    Safety Info

    HS Code 2933399090
    Symbol GHS07
    Hazard Declaration H315; H319; H335
    Signal Word Warning
    Caution Statement P261; P305 + P351 + P338
     

    Synthesis Route

    3-methylpyridine→3-pyridinecarbonitrile+3-(Aminomethyl)pyridine
    3-methylpyridine→pyridine-3-carbaldehyde+3-​Pyridinecarboxamide
    3-pyridinecarbonitrile+Formaldehyde→N-(hydroxymethyl)pyridine-3-carboxamide+3-​Pyridinecarboxamide
     

    GC Analysis

    Column typeActive phaseTemperature (°C)Retention Index (I)Temperature Control Method
    Capillary DB-5 - 1426. temperature ramp
     

    Precursor

    3-Iodopyridine
    3-pyridinecarbonitrile
    3-bromopyridine
    carbon monoxide
     

    Downstream Product

    2,3,4,6-Tetra-O-acetyl-β-D-glucose
    nicotinamide hydrobromide
    3-(3-carbamoylpyridin-1-ium-1-yl)propanoic acid,bromide
    3-carbamoyl-1-(tetra-O-acetyl-α-D-glucopyranosyl)-pyridinium, bromide

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