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3-O-methyl 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

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Origin: China

Cas No: 99522-79-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 99522-79-9 Formula: C25H24N2O6 Molecular Weight: 448.46800

Description

Pranidipine is a calcium channel blocker. It is a long acting calcium channel antagonist of the dihydropyridine group.

Basic Info

Chemical Name	3-O-methyl 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Synonyms	Pranidipine; FRC 8411;
CAS No.	99522-79-9
Molecular Formula	C25H24N2O6
Molecular Weight	448.46800
PSA	110.45000
LogP	5.11120

Properties

Appearance & Physical State	yellow solid
Density	1.253g/cm3
Boiling Point	618.9ºC at 760mmHg
Melting Point	140-142ºC
Flash Point	328.1ºC
Refractive Index	1.606

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - rat	2968 mg/kg	1.Sense Organs and Special Senses (Eye)-effect, not otherwise specified 2.Behavioral-somnolence (general depressed activity) 3.Nutritional and Gross Metabolic-body temperature decrease
Intraperitoneal	LD50 - Lethal dose, 50 percent kill	Rodent - rat	166 mg/kg	1.Gastrointestinal-hypermotility, diarrhea 2.Blood-normocytic anemia 3.Nutritional and Gross Metabolic-body temperature decrease
Subcutaneous	LD50 - Lethal dose, 50 percent kill	Rodent - rat	1670 mg/kg	1.Sense Organs and Special Senses (Eye)-ptosis 2.Skin and Appendages-dermatitis, other (after systemic exposure) 3.Nutritional and Gross Metabolic-body temperature decrease

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