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(2S,4S)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

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Origin: China

Cas No: 203866-13-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
203866-13-1
MF:
203866-13-1
EINECS No.:
203866-13-1
Type:
Pharmaceutical Intermediates
Purity:
0.99
Application:
Pharmaceutical intermediates
Appearance:
powder
Product Name:
CAS No. 203866-13-1
Type of product:
pharmaceutical raw material
Grade:
Medical Grade
Packaging&Delivery
Selling Units:
Single item
Single package size:
15X10X10 cm
Single gross weight:
1.000 kg
Package Type:
```
According to the customer demand
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Lead Time:
Quantity(Kilograms) 1 - 10 >10
Est. Time(days) 5 To be negotiated

Property

CAS No.: 203866-13-1 Formula: C10H16FNO4 Molecular Weight: 233.23700

Basic Info

Chemical Name	(2S,4S)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
Synonyms	Boc-cis-4F-Pro; (2S,4S)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid; (4S)-1-(tert-butoxycarbonyl)-4-fluoro-L-proline; BOC-FLP-OH; (2S,4S)-N-Boc-4-fluoroproline; BOC-CIS-PRO(4-F)-OH; (2S,4S)-1-(tert-Butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid; N-Boc-cis-4-fluoro-L-proline; BOC-CIS-4-FLUORO-PRO-OH; (2S,4S)-1-Boc-4-fluoro-2-pyrrolidinecarboxylic Acid; 1-(tert-butoxycarbonyl)-(4S)-fluoropyrrolidine-(2S)-carboxylic acid; BOC-CIS-4-FLUORO-L-PROLINE; N-(tert-Butoxycarbonyl)-cis-4-fluoro-L-proline; N-tert-butoxycarbonyl-cis-4-fluoro-L-proline; 1-(tert-butoxycarbonyl)-(4S)-fluoro-(2S)-pyrrolidinylcarboxylic;
CAS No.	203866-13-1
Molecular Formula	C10H16FNO4
Molecular Weight	233.23700
PSA	66.84000
LogP	1.35640

Properties

Density	1.24 g/cm3
Boiling Point	346ºC at 760 mmHg
Melting Point	157-161.ºC
Flash Point	163ºC
Vapor Pressure	1.05E-05mmHg at 25°C

Safety Info

Safety Statements	S26
HS Code	2933990090
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

1-O-tert-butyl 2-O-methyl (2S)-2,5-dihydropyrrole-1,2-dicarboxylate+1-O-tert-butyl 2-O-methyl (2S)-2,3-dihydropyrrole-1,2-dicarboxylate→(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]-2,3-dihydropyrrole-2-carboxylic acid+(2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]-2,5-dihydropyrrole-2-carboxylic acid
(2S,4S)-1-tert-Butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate→(2S,4S)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
N-tert-butoxycarbonyl-(2S,4S)-4-fluoroproline benzyl ester→(2S,4S)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

Precursor

N-tert-butoxycarbonyl-(2S,4S)-4-fluoroproline benzyl ester
tert-butoxycarbonyl anhydride
N-Boc-trans-4-hydroxy-L-proline benzyl ester
N-Boc-trans-4-Hydroxy-L-proline methyl ester

Downstream Product

(2S,4S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid
(2S,4S)-1-Boc-2-cyano-4-fluoropyrrolidine

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