Home > Organosilicon Compounds> (2S,4R)-4-[tert-butyl(dimethyl)silyl]oxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

(2S,4R)-4-[tert-butyl(dimethyl)silyl]oxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

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Origin: China

Cas No: 149814-40-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 149814-40-4 Formula: C16H31NO5Si Molecular Weight: 345.50700

Basic Info

Chemical Name	(2S,4R)-4-[tert-butyl(dimethyl)silyl]oxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
Synonyms	N-Boc-trans-4-tert-butyldimethylsiloxy-L-proline;
CAS No.	149814-40-4
Molecular Formula	C16H31NO5Si
Molecular Weight	345.50700
PSA	76.07000
LogP	3.40870

Synthesis Route

(2S,4R)-1-Boc-2-methylcarboxylate-4-tert-butyldimethylsilyloxy-pyrrolidine→(2S,4R)-4-[tert-butyl(dimethyl)silyl]oxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
tert-butoxycarbonyl anhydride→(2S,4R)-4-[tert-butyl(dimethyl)silyl]oxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
N-Boc-trans-4-Hydroxy-L-proline methyl ester→(2S,4R)-4-[tert-butyl(dimethyl)silyl]oxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

Precursor

tert-butoxycarbonyl anhydride
(2S,4R)-1-Boc-2-methylcarboxylate-4-tert-butyldimethylsilyloxy-pyrrolidine
N-Boc-trans-4-Hydroxy-L-proline methyl ester
(2S,4R)-4-hydroxypyrrolidine-2-carbonyl chloride

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