Home > Chiral Compounds> (2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

(2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

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Origin: China

Cas No: 186132-96-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 186132-96-7 Formula: C10H17NO5 Molecular Weight: 231.24600

Description

Boc-cis-3-hydroxy-L-proline is used to prepare analogs of cyclothialidine, a DNA-gyrase inhibitor with antibacterial activities. It is also used to synthesize potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors.

Basic Info

Chemical Name	(2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
Synonyms	Boc-cis-3-hydroxy-L-proline; N-tert-butyloxycarbonyl-cis-3-hydroxy-L-proline;
CAS No.	186132-96-7
Molecular Formula	C10H17NO5
Molecular Weight	231.24600
PSA	87.07000
LogP	0.37920

Properties

Density	1.312g/cm3
Boiling Point	390.873ºC at 760 mmHg
Flash Point	190.193ºC
Refractive Index	1.531
Storage Condition	Store at RT
Vapor Pressure	0mmHg at 25°C

Synthesis Route

tert-butoxycarbonyl anhydride+(2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid→(2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
N-tert-butyloxycarbonyl-cis-3-hydroxy-L-proline benzyl ester→(2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
N-tert-butoxycarbonyl-cis-3-(p-nitrobenzoyloxy)-L-proline methyl ester→(2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

Precursor

N-tert-butoxycarbonyl-cis-3-(p-nitrobenzoyloxy)-L-proline methyl ester
tert-butoxycarbonyl anhydride
N-tert-butyloxycarbonyl-cis-3-hydroxy-L-proline benzyl ester
(2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid

Downstream Product

(3S)-3-Fluoro-L-proline

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