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(2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

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Origem: China

Cas No: 186132-96-7

Especificação: 99%Min

Quantidade de ordem min: 1 /kg

Capacidade de fornecimento: 80 mt/month

Tempo de espera: 7 dias para OEM, 3 dias para produtos prontos

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    CAS No.: 186132-96-7 Formula: C10H17NO5 Molecular Weight: 231.24600

    Description

    Boc-cis-3-hydroxy-L-proline is used to prepare analogs of cyclothialidine, a DNA-gyrase inhibitor with antibacterial activities. It is also used to synthesize potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors.

    Basic Info

    Chemical Name (2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
    Synonyms

    Boc-cis-3-hydroxy-L-proline;
    N-tert-butyloxycarbonyl-cis-3-hydroxy-L-proline;

    CAS No. 186132-96-7
    Molecular Formula C10H17NO5
    Molecular Weight 231.24600
    PSA 87.07000
    LogP 0.37920

    Properties

    Density 1.312g/cm3
    Boiling Point 390.873ºC at 760 mmHg
    Flash Point 190.193ºC
    Refractive Index 1.531
    Storage Condition Store at RT
    Vapor Pressure 0mmHg at 25°C

    Synthesis Route

    tert-butoxycarbonyl anhydride+(2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid(2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
    N-tert-butyloxycarbonyl-cis-3-hydroxy-L-proline benzyl ester(2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
    N-tert-butoxycarbonyl-cis-3-(p-nitrobenzoyloxy)-L-proline methyl ester(2S,3R)-3-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

    Precursor

    N-tert-butoxycarbonyl-cis-3-(p-nitrobenzoyloxy)-L-proline methyl ester
    tert-butoxycarbonyl anhydride
    N-tert-butyloxycarbonyl-cis-3-hydroxy-L-proline benzyl ester
    (2S,3R)-3-hydroxypyrrolidine-2-carboxylic acid

    Downstream Product

    (3S)-3-Fluoro-L-proline

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