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(2R,3R,4S,5R)-2-(6-amino-2-iodopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

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Origin: China

Cas No: 35109-88-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
35109-88-7
Other Names:
2-iodoadenosine
MF:
C10H12IN5O4
EINECS No.:
1592732-453-0
Place of Origin:
Anhui, China
Type:
Pharmaceutical Intermediates
Purity:
99%
Brand Name:
Leah chem
Model Number:
Leah 35109-88-7
Application:
API
Appearance:
White to yellow powder
Product name:
2-IODOADENOSINE
Synonyms:
2-IODOADENOSINE
CAS:
35109-88-7
EINECS:
1592732-453-0
Molecular formula:
C10H12IN5O4
Molecular Weight:
393.13785
Assay:
99%minn
Certification:
COA
Color:
White to yellow
Brand:
Leah chem
Packaging&Delivery
Packaging Details
25kgs/drum
Port
Shanghai
Lead Time:
Quantity(Grams) 1 - 2000 >2000
Est. Time(days) 2 To be negotiated

Property

CAS No.: 35109-88-7 Formula: C10H12IN5O4 Molecular Weight: 393.13800

Description

An intermediate in the synthesis of isoguanosine (crotonoside or 2-hydroxyadenosine), a naturally occuring nucleoside analogue of guanosine. Isoguanosine is incorporated into mammalian but not bacterial nucleic acids, stimulates the accumulation of cyclic AMP in the brain, and is an inhibitor of IMP:pyrophosphorylase.

Basic Info

Chemical Name	(2R,3R,4S,5R)-2-(6-amino-2-iodopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Synonyms	2-IODOADENOSINE; 2-iodo-2',3'-O-isopropylidene-adenosine; Adenosine,2-iodo; 2-idodadenosine; 6-Amino-2-iodo-9-(β-D-ribofuranosyl)purine; 2-Iodo-D-adenosine;
CAS No.	35109-88-7
Molecular Formula	C10H12IN5O4
Molecular Weight	393.13800
PSA	139.54000
LogP	-0.79420

Properties

Appearance & Physical State	Off-white crystalline solid
Density	2.69 g/cm3
Boiling Point	776.3ºC at 760 mmHg
Melting Point	200ºC (dec.)
Flash Point	423.3ºC
Refractive Index	1.994

Safety Info

Safety Statements	S26
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

6-Chloro-2-iodo-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine→(2R,3R,4S,5R)-2-(6-amino-2-iodopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2S,3R,4S,5R)-2-((6-Chloro-2-iodo-9H-purin-9-yl)-oxy)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol→(2R,3R,4S,5R)-2-(6-amino-2-iodopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate→(2R,3R,4S,5R)-2-(6-amino-2-iodopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Precursor

(2S,3R,4S,5R)-2-((6-Chloro-2-iodo-9H-purin-9-yl)-oxy)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
2-amino-6-chloro-9-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)purine
(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-amino-6-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
6-Chloro-2-iodo-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine

Downstream Product

(2S,3S,4R,5R)-5-(6-amino-2-hex-1-ynylpurin-9-yl)-3,4-dihydroxyoxolane-2-carboxamide
adenosine
(2R,3R,4S,5R)-2-[6-amino-2-(3-cyclopentylprop-1-ynyl)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
2-Hydrazino Adenosine

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