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2,4-Dichloro-6,7-dimethoxyquinazoline

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Origin: China

Cas No: 27631-29-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 27631-29-4 Formula: C10H8Cl2N2O2 Molecular Weight: 259.08900

Description

An intermediate in the preparation of potential inhibitors of epidermal growth factor receptor kinases. An intermediate in the preparation of Terazosin.

Basic Info

Chemical Name	2,4-Dichloro-6,7-dimethoxyquinazoline
Synonyms	2,4-Dichloro-6,7-diMethoxyquinazoline; 2,4-DICHLORO-6,7-DIMETHOXYQUINAZOLINETERAZOSIN; 2,4-Dichlor-6,7-dimethoxy-chinazolin; 7-diMethoxyquinoazoline; 2-Chloro-6,7-diMethoxyquinazolin-4-yl Chloride; 2,4-Dichloro-6,7-dimethoxyquin; 2,4-Dichloro-6,7-dimethoxyxinazoline; 2,4-dichloro-6,7-dimethoxy-quinazoline; 2,4-Dichloro-6,7-dimethoxyquinoazoline; 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one;
CAS No.	27631-29-4
Molecular Formula	C10H8Cl2N2O2
Molecular Weight	259.08900
PSA	44.24000
LogP	2.95380

Properties

Appearance & Physical State	white powder
Density	1.424 g/cm3
Boiling Point	340.5ºC at 760 mmHg
Melting Point	172-177ºC
Flash Point	159.7ºC
Refractive Index	1.614
Vapor Pressure	0mmHg at 25°C

Safety Info

Safety Statements	S26-S37/39
HS Code	2933990090
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

6,7-Dimethoxyquinazoline-2,4-dione→2,4-Dichloro-6,7-dimethoxyquinazoline
bis(trichloromethyl) carbonate+2-Amino-4,5-dimethoxybenzonitrile→2,4-Dichloro-6,7-dimethoxyquinazoline
Methyl 3,4-dimethoxybenzoate→2,4-Dichloro-6,7-dimethoxyquinazoline

Precursor

Methyl 3,4-dimethoxybenzoate
2-Amino-4,5-dimethoxybenzonitrile
Methyl 4,5-dimethoxy-2-nitrobenzoate
bis(trichloromethyl) carbonate

Downstream Product

2-Chloro-4-amino-6,7-dimethoxyquinazoline
1-[6,7-dimethoxy-2-(2-phenylhydrazinyl)quinazolin-4-yl]-2-phenylhydrazine,hydrochloride
2-CHLORO-6,7-DIMETHOXYQUINAZOLINE
1-(2-chloro-6,7-dimethoxyquinazolin-4-yl)oxy-3-(propan-2-ylamino)propan-2-ol

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