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2-Chloro-2',4'-difluoroacetophenone

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Origin: China

Cas No: 51336-94-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 51336-94-8 Formula: C8H5ClF2O Molecular Weight: 190.57500

Description

A α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B.

Basic Info

Chemical Name	2-Chloro-2',4'-difluoroacetophenone
Synonyms	2-Chloro-1-(2,4-difluorophenyl)ethanone; 2,4-Difluorophenacyl Chloride;
CAS No.	51336-94-8
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57500
PSA	17.07000
LogP	2.38630

Properties

Appearance & Physical State	white crystalline powder
Density	1.353 g/cm3
Boiling Point	240.9ºC at 760 mmHg
Melting Point	44-48ºC
Flash Point	>230 °F
Refractive Index	1.526
Storage Condition	-20ºC Freezer, Under Inert Atmosphere

Safety Info

Hazard Class	8
Safety Statements	S25-S36/37/39-S45
HS Code	2914700090
WGK Germany	3
Packing Group	II
RIDADR	UN 3261
Risk Statements	R34
Hazard Codes	C
Symbol	GHS05
Signal Word	Danger
Caution Statement	P280; P305 + P351 + P338; P310
Hazard Declaration	H314

Synthesis Route

1,3-difluorobenzene+Chloroacetyl chloride→2-Chloro-2',4'-difluoroacetophenone
1,3-difluorobenzene+chloroacetone→2-Chloro-2',4'-difluoroacetophenone

Precursor

Chloroacetyl chloride
1,3-difluorobenzene
chloroacetone

Downstream Product

Posaconazole
1-(2,4-difluorophenyl)-2-hydroxyethanone
methyl 3-(2,4-difluorophenyl)-3-oxopropanoate
(R)-2-(2,4-difluoro-phenyl)-3-[1H-1,2,4]triazoll-1-yl-propane-1,2-diol?

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