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2-aminoadipic acid

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Origin: China

Cas No: 542-32-5

Specification: 99%min

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 542-32-5 Formula: C6H11NO4 Molecular Weight: 161.15600

    Description

    α-Aminoadipic acid is an intermediate in the α-Aminoadipic acid pathway for the metabolism of lysine and saccharopine. It is synthesised from homoisocitrate by aminoadipate aminotransferase and reduced by aminoadipate reductase to form the semialdehyde.
    A 2013 study identified α-Aminoadipic acid (2-aminoadipic acid) as a novel predictor of the development of diabetes and suggested that it is a potential modulator of glucose homeostasis in humans.

    Basic Info

    Chemical Name 2-aminoadipic acid
    Synonyms

    DL-2-Aminoadipic acid;
    L-2-Aminohexanedioic acid;
    .α.-Aminoadipic acid;

    CAS No. 542-32-5
    Molecular Formula C6H11NO4
    Molecular Weight 161.15600
    PSA 100.62000
    LogP 0.35350

    Properties

    Appearance & Physical State crystalline
    Density 1.333g/cm3
    Boiling Point 364ºC at 760mmHg
    Melting Point 196-198ºC
    Flash Point 173.9ºC
    Storage Condition 2-8ºC

    Safety Info

    Safety Statements S24/25
    HS Code 2922499990
    Risk Statements R36/37/38
    Hazard Codes Xi
    Symbol GHS07
    Hazard Declaration H317
    Caution Statement P280
    Signal Word Warning

    Synthesis Route

    2-oxoadipic acid→2-aminoadipic acid+2-hydroxyadipic acid
    2-phenyl-3-succinylidene-5-oxazolone→2-aminoadipic acid
    2-oxoadipic acid→2-aminoadipic acid

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Intraperitoneal LD - Lethal dose Rodent - rat >500 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    diethyl 2-bromoadipate
    2-oxoadipic acid
    adipic acid
    ethyl 1-cyclohexanecarbonyl-6-oxo-2-piperidinecarboxylate

    Downstream Product

    (2R)-6-oxopiperidine-2-carboxylic acid
    6-Oxo-piperidine-2-carboxylic acid
    L-lysine
    D,L-Homoglutamine

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