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12(S)-HETE

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Origin: China

Cas No: 54397-83-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 54397-83-0 Formula: C20H32O3 Molecular Weight: 320.46600

Description

A fatty acid metabolite of arachidonic acid. Potential biomarker for asthma monitoring and diagnosis. Stimulates protein kinase C-mediated release of cathepsin B from malignant cells. Used in the study of mechanisms controlling cell cycle arrest and induction of apoptosis in prostate cancer cells via 12-lipoxygenase inhibition..

Basic Info

Chemical Name	12(S)-HETE
Synonyms	12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid;
CAS No.	54397-83-0
Molecular Formula	C20H32O3
Molecular Weight	320.46600
PSA	57.53000
LogP	5.18750

Properties

Density	0.984 g/cm3
Boiling Point	487.7ºC at 760 mmHg
Flash Point	14ºC
Refractive Index	1.513
Storage Condition	-20ºC

Safety Info

Safety Statements	S7-S16-S26-S36
HS Code	2918199090
RIDADR	UN 1170 3/PG 2
Risk Statements	R11
Hazard Codes	F; Xi
Hazard Declaration	H225; H319
Caution Statement	P210; P280; P305 + P351 + P338; P337 + P313; P403 + P235
Signal Word	Danger
Symbol	GHS02, GHS07

Synthesis Route

arachidonic acid→thromboxane B2+prostaglandin E2
methyl pyridazine-3-carbimidate→12(S)-HETE
2(S)-[(tert-butyldiphenylsilyl)oxy]-4(Z)-decenal→12(S)-HETE

Precursor

6,6,6-trimethoxyhex-1-yne
O,O-Bicyclohexyl-1,1'-diyl thiosulphite
2(S)-[(tert-butyldiphenylsilyl)oxy]-4(Z)-decenal
methyl pyridazine-3-carbimidate

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