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15(S)-HETE

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Origin: China

Cas No: 54845-95-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 54845-95-3 Formula: C20H32O3 Molecular Weight: 320.46600

    Description

    15-Hydroxyicosatetraenoic acid (also termed 15-HETE, 15(S)-HETE, and 15S-HETE) is an endogenous eicosanoid, i.e. a metabolite of arachidonic acid. Various cell types and tissues first produce 15-Hydroperoxyicosatetraenoic acid (15-HpETE). These initial hydroperoxy products are extremely short lived in cells: if not otherwise metabolized, they are reduced to 15-HETE. Both these molecules are are hormone-like autocrine and paracrine signalling agents, involved in inflammation response, but often are further metabolized to a wide range of products that are much more potent, including eoxins.
    The production and actions of these molecules and their metabolites often differ greatly depending on cell-type or tissue-type studied. In many ways they are analogous to the more abundant 5-HETE and 5-HPETE.

    Basic Info

    Chemical Name 15(S)-HETE
    Synonyms

    15(S)-Hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid;
    (5Z,8Z,11Z,13E,15S)-15-hydroxyicosa-5,8,11,13-tetraenoic acid;

    CAS No. 54845-95-3
    Molecular Formula C20H32O3
    Molecular Weight 320.46600
    PSA 57.53000
    LogP 5.18750

    Properties

    Density 0.984 g/cm3
    Boiling Point 487.7ºC at 760 mmHg
    Flash Point 262.8ºC
    Refractive Index 1.513
    Storage Condition -20ºC

    Safety Info

    Safety Statements 7-16-26-36
    HS Code 2918199090
    RIDADR UN 1170 3
    Risk Statements R11
    Hazard Codes F; Xi

    Synthesis Route

    15(S)-HPETE→15(S)-HETE
    methyl (5E,8Z,11Z,13Z,15S)-15-hydroxyicosa-5,8,11,13-tetraenoate→15(S)-HETE
    5-HEXYN-1-OL→15(S)-HETE

    Precursor

    5-HEXYN-1-OL
    tert-butyl-hex-5-ynoxy-dimethylsilane
    methyl (5E,8Z,11Z,13Z,15S)-15-hydroxyicosa-5,8,11,13-tetraenoate
    15(S)-HPETE

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