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(+)-pilocarpine

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Origin: China

Cas No: 92-13-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 92-13-7 Formula: C11H16N2O2 Molecular Weight: 208.25700

Description

Pilocarpine is a drug used to treat dry mouth and glaucoma. It is a parasympathomimetic alkaloid obtained from the leaves of tropical South American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at the muscarinic acetylcholine receptor M3 due to its topical application, e.g., in glaucoma and xerostomia.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Basic Info

Chemical Name	(+)-pilocarpine
Synonyms	ocusertp20; actone; pilokarpol; Syncarpine; Pilokarpin; Pilocarpin; 2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S-cis)-; PILOCARPINE; Ocucarpine; Ocusert; Pilocarpol;
CAS No.	92-13-7
Molecular Formula	C11H16N2O2
Molecular Weight	208.25700
PSA	44.12000
LogP	1.16180

Properties

Density	1.22 g/cm3
Boiling Point	260ºC at 5 MM HG (PARTIALºCONVERSION TO ISOPILºCARPINE)
Flash Point	215ºC

Safety Info

Hazard Class	6.1(b)
Safety Statements	S25; S45
Packing Group	III
RIDADR	UN 1544
Risk Statements	R26/28
Hazard Codes	T+

Synthesis Route

3-ethyl-dihydro-4-[(1-methyl-1H-2-mercaptoimidazol-5-yl)methyl]-2(3H)-furanone→(+)-pilocarpine
4-toluene-sulfonylmethyl isocyanide+2-(4-ethyl-5-oxooxolan-3-yl)acetaldehyde→(+)-pilocarpine
α-Acetylbutyrolactone→(+)-pilocarpine

GC Analysis

Column type	Active phase	Temperature (°C)	Retention Index (I)	Temperature Control Method
Packed	SE-30	220.	2060.	isothermal
Other	Methyl Silicone	-	2014.	custom temperature program

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Subcutaneous	LDLo - Lowest published lethal dose	Human	143 ug/kg	1.Behavioral-coma 2.Lungs, Thorax, or Respiration-cyanosis 3.Vascular-BP elevation not characterized in autonomic section
Subcutaneous	TDLo - Lowest published toxic dose	Human - woman	1143 ug/kg	1.Lungs, Thorax, or Respiration-dyspnea 2.Gastrointestinal-changes in structure or function of salivary glands 3.Skin and Appendages-sweating
Unreported	LDLo - Lowest published lethal dose	Human - man	1912 ug/kg	1.Details of toxic effects not reported other than lethal dose value

Precursor

α-Acetylbutyrolactone
3-ethyl-dihydro-4-[(1-methyl-1H-2-mercaptoimidazol-5-yl)methyl]-2(3H)-furanone
4-toluene-sulfonylmethyl isocyanide
2-(4-ethyl-5-oxooxolan-3-yl)acetaldehyde

Downstream Product

butyric acid
1,5-dimethylimidazole
(+)-pilocarpine
METHYLAMINE

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