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(+)-pilocarpine

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Origin: China

CasNo: 92-13-7

specification: 99%min

Min order Quantity: 1 /kg

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  • Products Specification
  • Description
  • Property

    CAS No.: 92-13-7 Formula: C11H16N2O2 Molecular Weight: 208.25700

    Description

    Pilocarpine is a drug used to treat dry mouth and glaucoma. It is a parasympathomimetic alkaloid obtained from the leaves of tropical South American shrubs from the genus Pilocarpus. It is a non-selective muscarinic receptor agonist in the parasympathetic nervous system, which acts therapeutically at the muscarinic acetylcholine receptor M3 due to its topical application, e.g., in glaucoma and xerostomia.
    It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

    Basic Info

    Chemical Name (+)-pilocarpine
    Synonyms

    ocusertp20;
    actone;
    pilokarpol;
    Syncarpine;
    Pilokarpin;
    Pilocarpin;
    2(3H)-Furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S-cis)-;
    PILOCARPINE;
    Ocucarpine;
    Ocusert;
    Pilocarpol;

    CAS No. 92-13-7
    Molecular Formula C11H16N2O2
    Molecular Weight 208.25700
    PSA 44.12000
    LogP 1.16180

    Properties

    Density 1.22 g/cm3
    Boiling Point 260ºC at 5 MM HG (PARTIALºCONVERSION TO ISOPILºCARPINE)
    Flash Point 215ºC

    Safety Info

    Hazard Class 6.1(b)
    Safety Statements S25; S45
    Packing Group III
    RIDADR UN 1544
    Risk Statements R26/28
    Hazard Codes T+

    Synthesis Route

    3-ethyl-dihydro-4-[(1-methyl-1H-2-mercaptoimidazol-5-yl)methyl]-2(3H)-furanone(+)-pilocarpine
    4-toluene-sulfonylmethyl isocyanide+2-(4-ethyl-5-oxooxolan-3-yl)acetaldehyde(+)-pilocarpine
    α-Acetylbutyrolactone(+)-pilocarpine

    GC Analysis

    Column type Active phase Temperature (°C) Retention Index (I) Temperature Control Method
    Packed SE-30 220. 2060. isothermal
    Other Methyl Silicone - 2014. custom temperature program

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Subcutaneous LDLo - Lowest published lethal dose Human 143 ug/kg 1.Behavioral-coma
    2.Lungs, Thorax, or Respiration-cyanosis
    3.Vascular-BP elevation not characterized in autonomic section
    Subcutaneous TDLo - Lowest published toxic dose Human - woman 1143 ug/kg 1.Lungs, Thorax, or Respiration-dyspnea
    2.Gastrointestinal-changes in structure or function of salivary glands
    3.Skin and Appendages-sweating
    Unreported LDLo - Lowest published lethal dose Human - man 1912 ug/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    α-Acetylbutyrolactone
    3-ethyl-dihydro-4-[(1-methyl-1H-2-mercaptoimidazol-5-yl)methyl]-2(3H)-furanone
    4-toluene-sulfonylmethyl isocyanide
    2-(4-ethyl-5-oxooxolan-3-yl)acetaldehyde

    Downstream Product

    butyric acid
    1,5-dimethylimidazole
    (+)-pilocarpine
    METHYLAMINE

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