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Picture of (±)-Anatoxin A fumarate,(±)-2-Acetyl-9-azabicyclo[4.2.1]non-2-enefumarate

(±)-Anatoxin A fumarate,(±)-2-Acetyl-9-azabicyclo[4.2.1]non-2-enefumarate

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Origin: China

CasNo: 64285-06-9

specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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  • Products Specification
  • Description
  • Property

    CAS No.: 64285-06-9 Formula: C10H15NO Molecular Weight: 165.23200

    Description

    Anatoxin-a, also known as Very Fast Death Factor (VFDF), is a secondary, bicyclic amine alkaloid and cyanotoxin with acute neurotoxicity. It was first discovered in the early 1960s in Canada, and was isolated in 1972. The toxin is produced by seven different genera of cyanobacteria and has been reported in North America, Europe, Africa, Asia, and New Zealand. Symptoms of anatoxin exposure include loss of coordination, muscular fasciculations, convulsions and death by respiratory paralysis. Its mode of action is through the nicotinic acetylcholine receptor (nAchR) where it acts as an agonist of acetylcholine. As such, anatoxin-a has been used for medicinal purposes to investigate diseases characterized by low acetylcholine levels. Due to its high toxicity and potential presence in drinking water, anatoxin-a poses a threat to animals, including humans. While methods for detection and water treatment exist, scientists have called for more research to improve reliability and efficacy. Anatoxin-a is not to be confused with anatoxin-a(S), another potent cyanotoxin that has a similar mechanism of action to that of anatoxin-a and is produced by many of the same cyanobacteria genera, but is structurally unrelated.

    Basic Info

    Chemical Name (±)-Anatoxin A fumarate,(±)-2-Acetyl-9-azabicyclo[4.2.1]non-2-enefumarate
    Synonyms

    Anatoxin 1;
    anatoxini;
    Antx-a;

    CAS No. 64285-06-9
    Molecular Formula C10H15NO
    Molecular Weight 165.23200
    PSA 29.10000
    LogP 1.74500

    Properties

    Appearance & Physical State Lyophilized Solid
    Density 1.037 g/cm3
    Boiling Point 291ºC at 760 mmHg
    Flash Point 124.7ºC
    Refractive Index 1.503
    Storage Condition Desiccate at +4ºC

    Safety Info

    HS Code 2933990090

    Synthesis Route

    (1R)-2-acetyl-9-(benzyloxycarbonyl)-9-azabicyclo[4.2.1]-2-nonene(±)-Anatoxin A fumarate,(±)-2-Acetyl-9-azabicyclo[4.2.1]non-2-enefumarate
    (-)-N-tosylanatoxin-a(±)-Anatoxin A fumarate,(±)-2-Acetyl-9-azabicyclo[4.2.1]non-2-enefumarate
    (-)-(5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-1-tosylpyrrolidin-2-one(±)-Anatoxin A fumarate,(±)-2-Acetyl-9-azabicyclo[4.2.1]non-2-enefumarate

    Precursor

    (-)-(5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-1-tosylpyrrolidin-2-one
    (2R,5R)-2-(but-3-en-1-yl)-5-methoxy-1-tosylpyrrolidine
    (1R)-2-acetyl-9-(benzyloxycarbonyl)-9-azabicyclo[4.2.1]-2-nonene
    ((2S,5R)-5-methoxy-1-tosylpyrrolidin-2-yl)methanol

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