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zoledronic acid

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Origin: China

Cas No: 118072-93-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
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    CAS No.: 118072-93-8 Formula: C5H10N2O7P2 Molecular Weight: 272.09000

    Description

    Zoledronic acid (INN) or zoledronate is a bisphosphonate drug given intravenously to treat some bone diseases. It is sold under many trade names worldwide.

    Basic Info

    Chemical Name zoledronic acid
    Synonyms

    Zometa,Zomera,Aclasta and Reclast;
    [1-Hydroxy-2-(1H-imidazol-1-yl)-ethylidene]bisphosphonic acid;
    Zoledronic acid monohydrate;
    Zoledronic acid;
    Phosphonic acid (P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis;
    P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate;
    (1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl)diphosphonic acid;
    [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate;

    CAS No. 118072-93-8
    Molecular Formula C5H10N2O7P2
    Molecular Weight 272.09000
    PSA 172.73000
    LogP -1.11540

    Properties

    Appearance & Physical State white crystalline powder
    Density 2.13 g/cm3
    Boiling Point 764ºC at 760 mmHg
    Melting Point 193-2040ºC
    Flash Point 415.8ºC
    Refractive Index 1.718
    Vapor Pressure 1.53E-24mmHg at 25°C

    Safety Info

    Safety Statements S24/25; S36/37/39
    HS Code 2933290090
    Risk Statements R21/22
    Hazard Codes Xi

    Synthesis Route

    2-imidazol-1-ylacetic acidzoledronic acid
    imidazol-1-yl-acetyl chloridezoledronic acid
    zoledronate sodiumzoledronic acid

    Precursor

    phosphorus trichloride
    tetrakis(O-trimethylsilyl)hydroxyethylidenediphosphonic acid
    2-imidazol-1-ylacetic acid
    imidazol-1-yl-acetyl chloride

    Downstream Product

    Zoledronic acid hydrate

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