Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> warfarin

warfarin

Get Latest Price >

FOB Price contact us for price

Origin: China

Cas No: 81-81-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

Vendor:

Payment Terms:

Inquiry now

* Send an Inquiry to us

Add to wishlist

* Name your price
* Start order doesn't mean buying now

Products Specification
Product Description

Property

CAS No.: 81-81-2 Formula: C19H16O4 Molecular Weight: 308.32800

Description

Coumarin anticoagulant. Marketed as the racemate; the S-(-)-form is the more potent isomer. Anticoagulant.

Basic Info

Chemical Name	warfarin
Synonyms	accurb; rac-4-hydroxy-3-[(1R)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one; X 115; 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; duraphy; Nuelin; asmax; 1,3-dimethylxanthine; Unifyl; unidur; 4-hydroxy-3-[(1RS)-3-oxo-1-phenylbutyl]coumarin; austyn; Slo-PhyllinTM; 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-; Elixex; Warfarin; (RS)-3-(α-acetonylbenzyl)-4-hydroxycoumarin; zoocoumarin; 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione;
CAS No.	81-81-2
Molecular Formula	C19H16O4
Molecular Weight	308.32800
PSA	67.51000
LogP	3.60960

Properties

Appearance & Physical State	white to off-white crystalline powder
Density	1.307 g/cm3
Boiling Point	356ºC
Melting Point	162-164ºC
Flash Point	188.8ºC
Water Solubility	Practically insoluble
Stability	Contact with strong oxidizers may cause fires and explosions.
Storage Condition	2-8ºC

Safety Info

RTECS	GN4550000
Hazard Class	6.1(a)
Safety Statements	S52-S45-S61
WGK Germany	3
Packing Group	I
RIDADR	UN 2811 6
Risk Statements	R61; R48/25; R52/53
Hazard Codes	T

Synthesis Route

4-hydroxycoumarin+trans-benzylideneacetone→warfarin
4-hydroxycoumarin+benzylideneacetone→warfarin
4-hydroxycoumarin+4-hydroxy-4-phenylbutan-2-one→warfarin

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Human - woman	15 mg/kg/21W-I	1.Gastrointestinal-ulceration or bleeding from small intestine 2.Blood-change in clotting factors
Oral	LDLo - Lowest published lethal dose	Human	6667 ug/kg	1.Details of toxic effects not reported other than lethal dose value
Oral	TDLo - Lowest published toxic dose	Rodent - rat	11250 ug/kg/90D-I	1.Biochemical-Enzyme inhibition, induction, or change in blood or tissue levels-hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)