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Valsartan

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Origin: China

Cas No: 137862-53-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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Product Description

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CAS No.: 137862-53-4 Formula: C24H29N5O3 Molecular Weight: 435.51900

Description

Valsartan (trade name Diovan) is an angiotensin II receptor antagonist (commonly called an ARB, or angiotensin receptor blocker), that is selective for the type I (AT1) angiotensin receptor. Valsartan is mainly used for treatment of high blood pressure, congestive heart failure, and to increase the chances of living longer after a heart attack.

Basic Info

Chemical Name	Valsartan
Synonyms	Valsratan; Tareg; DIOVAN; Valsartane; Valsartan API; N-Valeryl-N-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]-L-valine; (S)-2-(N-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoic acid; L-Valsartan; N-(1-Oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine; 3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-butanoic acid; Nisis;
CAS No.	137862-53-4
Molecular Formula	C24H29N5O3
Molecular Weight	435.51900
PSA	112.07000
LogP	4.16170

Properties

Appearance & Physical State	white crystalline powder
Density	1.212g/cm3
Boiling Point	684.9ºC at 760 mmHg
Melting Point	116-117ºC
Flash Point	368ºC
Refractive Index	1.586
Storage Condition	Store in original container in a cool dark place.
Vapor Pressure	1.06E-19mmHg at 25°C

Safety Info

Safety Statements	S26; S37/39
HS Code	2933990090
WGK Germany	3
Risk Statements	R36/37/38
Hazard Codes	Xi

Synthesis Route

(4S)-4-isopropyl-3-pentanoyl-2-(2'-(2-(2-phenylpropan-2-yl)-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)oxazolidin-5-one→cumene+2'-[(1H-Tetrazol-5-yl)biphenyl-4-yl]methanol
N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeroyl-(L)-valine benzyl ester→Valsartan
(S)-4-isopropyl-3-pentanoyl-2-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-yl]oxazolidin-5-one→Valsartan

Precursor

(S)-Benzyl 2-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate
(2S)-3-methyl-2-{N-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-N'-(thiophene-2-carbonyl)-amino}-butanoic acid
N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeroyl-(L)-valine benzyl ester
(S)-4-isopropyl-3-pentanoyl-2-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-yl]oxazolidin-5-one

Downstream Product

hydrochlorothiazide

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