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trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol

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Origin: China

Cas No: 201855-60-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

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CAS No.: 201855-60-9 Formula: C19H22FNO Molecular Weight: 299.38200

Description

Paroxetine intermediate.

Basic Info

Chemical Name	trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol
Synonyms	[(3S,4R)-1-Benzyl-4-(4-fluorophenyl)piperidin-3-yl]methanol; Paroxetine hydrochloride;
CAS No.	201855-60-9
Molecular Formula	C19H22FNO
Molecular Weight	299.38200
PSA	23.47000
LogP	3.36160

Properties

Density	1.139g/cm3
Boiling Point	402.1ºC at 760 mmHg
Flash Point	197ºC
Refractive Index	1.571
Vapor Pressure	3.45E-07mmHg at 25°C

Synthesis Route

(3S,4R)-ethyl 1-benzyl-4-(4-fluorophenyl)-6-hydroxy-2-oxopiperidine-3-carboxylate→trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol
[(1S,4R)-4-hydroxycyclopent-2-en-1-yl] acetate→trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol
4-Fluorophenylmagnesium chloride→trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol

Precursor

(3R,7aS)-3-phenyl-3,6,7,7a-tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-5-one
[(1S,4R)-4-hydroxycyclopent-2-en-1-yl] acetate
(3S,4R)-ethyl 1-benzyl-4-(4-fluorophenyl)-6-hydroxy-2-oxopiperidine-3-carboxylate
4-Fluorophenylmagnesium chloride

Downstream Product

Paroxetine

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