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TPCA-1

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Origin: China

Cas No: 507475-17-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 507475-17-4 Formula: C12H10FN3O2S Molecular Weight: 279.29000

    Description

    TPCA-1 is a direct dual inhibitor for both IKKβ (IKK-2) and STAT3. It inhibits STAT3 phosphorylation, DNA binding, and transactivation in vivo. Synergistic treatment of TPCA-1 with tyrosine kinase inhibitors (TKIs) can potentially be a more effective method for treating cancers.

    Basic Info

    Chemical Name TPCA-1
    Synonyms

    IKK-2 Inhibitor IV;
    5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide;
    3qfv;
    2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide;
    GW683965 GW683965A [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide;

    CAS No. 507475-17-4
    Molecular Formula C12H10FN3O2S
    Molecular Weight 279.29000
    PSA 126.45000
    LogP 3.61730

    Properties

    Density 1.491g/cm3
    Boiling Point 442.576ºC at 760 mmHg
    Flash Point 221.462ºC
    Refractive Index 1.686
    Storage Condition 2-8ºC

    Safety Info

    Safety Statements S26
    Risk Statements R22; R36
    Hazard Codes Xn
    Caution Statement P301 + P312 + P330; P305 + P351 + P338
    Hazard Declaration H302; H319
    Symbol GHS07
    Signal Word Warning

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