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torasemide

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Origin: China

Cas No: 56211-40-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 56211-40-6 Formula: C16H20N4O3S Molecular Weight: 348.42000

    Description

    Used as a diuretic.

    Basic Info

    Chemical Name torasemide
    Synonyms

    GJ-1090;
    DEMADEX;
    LUPLAC;
    Unat;
    AC-4464;
    Luprac;
    Torsemide;
    TOREM;
    TORADIUR;
    JDL-464;
    Torasemide;

    CAS No. 56211-40-6
    Molecular Formula C16H20N4O3S
    Molecular Weight 348.42000
    PSA 108.57000
    LogP 4.46550

    Properties

    Appearance & Physical State crystalline solid
    Density 1.283 g/cm3
    Melting Point 163-164ºC
    Refractive Index 1.594
    Storage Condition Store in original container in a cool dark place.

    Safety Info

    RTECS UT7938000
    Safety Statements S26; S37/39
    HS Code 2935009090
    Risk Statements R36
    Hazard Codes Xi

    Synthesis Route

    4-(3-Methylphenyl)Amino-3-Pyridinesulfonamide+Isopropyl isocyanate→torasemide
    (1-Methylethyl)carbamic Acid Phenyl Ester+4-(3-Methylphenyl)Amino-3-Pyridinesulfonamide→torasemide
    4-(3-methylanilino)pyridine-3-sulfonamide,hydrochloride+Isopropyl isocyanate→torasemide

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat >5 gm/kg 1.Kidney, Ureter, Bladder-urine volume increased
    Intravenous LD50 - Lethal dose, 50 percent kill Rodent - rat >500 mg/kg 1.Behavioral-somnolence (general depressed activity)
    2.Lungs, Thorax, or Respiration-respiratory depression
    3.Kidney, Ureter, Bladder-urine volume increased
    Unreported LD50 - Lethal dose, 50 percent kill Rodent - rat >5 gm/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    (1-Methylethyl)carbamic Acid Phenyl Ester
    4-(3-methylanilino)pyridine-3-sulfonamide,hydrochloride
    Isopropyl isocyanate
    4-(3-Methylphenyl)Amino-3-Pyridinesulfonamide

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