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thromboxane B2

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Origin: China

Cas No: 54397-85-2

Specification: 99%min

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 54397-85-2 Formula: C20H34O6 Molecular Weight: 370.48000

    Description

    Thromboxane B2 is an inactive metabolite/product of thromboxane A2. It is almost completely cleared in the urine.
    It itself is not involved in platelet activation and aggregation in case of a wound, but its precursor, thromboxane A2, is. Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets). ; 2-(3,4-Di-hydroxyphenyl)-ethanol (DHPE) is a phenolic component of extra-virgin olive oil. An olive oil fraction containing DHPE can inhibit platelet aggregation and thromboxane B2 formation in vitro.

    Basic Info

    Chemical Name thromboxane B2
    Synonyms

    Thromboxane B2;

    CAS No. 54397-85-2
    Molecular Formula C20H34O6
    Molecular Weight 370.48000
    PSA 107.22000
    LogP 2.76940

    Properties

    Density 1.171 g/cm3
    Boiling Point 582.5ºC at 760 mmHg
    Flash Point 199.7ºC
    Refractive Index 1.56
    Storage Condition -20ºC

    Safety Info

    Safety Statements S22; S36
    Risk Statements R63
    Hazard Codes Xn

    Synthesis Route

    (Z)-7-((2S,3R,4R)-4-hydroxy-2-((E)-3-hydroxyoct-1-en-1-yl)-6-methoxytetrahydro-2H-pyran-3-yl)hept-5-enoic acid→thromboxane B2
    thromboxane B2 methyl glycoside→thromboxane B2
    (3aS,4S,6S,7aS)-4-((S,E)-1-hydroxyoct-2-en-1-yl)-6-methoxytetrahydro-4H-furo[3,2-c]pyran-2(3H)-one→thromboxane B2

    Precursor

    2-{(2S,3S,6S)-2-[(S)-1-Hydroxy-2-(4-methoxy-phenoxy)-ethyl]-6-methoxy-3,6-dihydro-2H-pyran-3-yl}-N,N-dimethyl-acetamide
    Acetic acid (E)-(S)-1-((3aS,4S,6S,7aS)-6-methoxy-2-oxo-hexahydro-furo[3,2-c]pyran-4-yl)-oct-2-enyl ester
    thromboxane B2 methyl glycoside
    (Z)-7-((2S,3R,4R)-4-hydroxy-2-((E)-3-hydroxyoct-1-en-1-yl)-6-methoxytetrahydro-2H-pyran-3-yl)hept-5-enoic acid

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