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thromboxane A2

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Origin: China

Cas No: 57576-52-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 57576-52-0 Formula: C20H32O5 Molecular Weight: 352.46500

    Description

    Thromboxane A2 (TXA2) is a type of thromboxane that is produced by activated platelets and has prothrombotic properties: it stimulates activation of new platelets as well as increases platelet aggregation. This is achieved by increasing expression of the glycoprotein complex GPIIb/IIIa on the cell membrane of platelets. The same effect is also achieved by ADP in platelet stimulation, which is blocked by clopidogrel. Circulating fibrinogen binds these receptors on adjacent platelets, further strengthening the clot. Thromboxane A2 is also a known vasoconstrictor and is especially important during tissue injury and inflammation. It is also regarded as responsible for Prinzmetal's angina.
    Receptors that mediate TXA2 actions are thromboxane A2 receptors. The human TXA2 receptor (TP) is a typical G protein-coupled receptor (GPCR) with seven transmembrane segments. In humans, two TP receptor splice variants - TPα and TPβ - have so far been cloned.

    Basic Info

    Chemical Name thromboxane A2
    Synonyms

    CAS No. 57576-52-0
    Molecular Formula C20H32O5
    Molecular Weight 352.46500
    PSA 75.99000
    LogP 3.81500

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