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thiouracil

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Origin: China

Cas No: 141-90-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 141-90-2 Formula: C4H4N2OS Molecular Weight: 128.15200

Description

Thiouracil refers both to a specific molecule consisting of a sulfated uracil, and a family of molecules based upon that structure.

Basic Info

Chemical Name	thiouracil
Synonyms	2-Thioxo-1,2,3,4-tetrahydropyrimidin-4-one; 2-Thiouracil; 2-TU; Nobilen; 2,3-dihydro-2-thioxo-(1H)pyrimidin-4-one; 2-Mercapto-4-hydroxypyrimidine; 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine; Thiouraci; 2-Mercapto-4-pyrimidone; tiouracyl; Thiouracil; THIURACIL; DERACIL; 4-Hydroxy-2-mercaptopyrimidine; 4(1H)-Pyrimidinone, 2,3-dihydro-2-thioxo-;
CAS No.	141-90-2
Molecular Formula	C4H4N2OS
Molecular Weight	128.15200
PSA	80.74000
LogP	0.43250

Properties

Appearance & Physical State	white to pale yellow crystalline powder
Density	1.46g/cm3
Boiling Point	337.2ºC at 760mmHg
Melting Point	340ºC
Flash Point	157.7ºC
Refractive Index	1.677
Water Solubility	0.5 g/L
Stability	Stable under normal temperatures and pressures.
Storage Condition	2-8ºC
Vapor Pressure	5.45E-05mmHg at 25°C

Safety Info

RTECS	YR1575000
Safety Statements	S36/37
HS Code	29335995
WGK Germany	3
Risk Statements	R40
Hazard Codes	Xn

Synthesis Route

1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-5-methyl-1H,3H-pyrimidin-4-on-2-thione→thiouracil+N-(1,3-dihydroxypropan-2-yl)acetamide
ethyl 3-(N-methylcyanamino)-2-butenoate→thiouracil+N-Methylthiourea
4-AMINO-2-MERCAPTOPYRIMIDINE→thiouracil

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Intraperitoneal	LDLo - Lowest published lethal dose	Rodent - rat	1500 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Oral	LD50 - Lethal dose, 50 percent kill	Rodent - mouse	3900 mg/kg	1.Details of toxic effects not reported other than lethal dose value
Oral	TDLo - Lowest published toxic dose	Rodent - rat	2100 mg/kg/4W-C	1.Endocrine-changes in thyroid weight

Precursor

1-[N-(1,3-dipivaloyloxyprop-2-yl)acetylaminomethyl]-5-methyl-1H,3H-pyrimidin-4-on-2-thione
thiourea
4-AMINO-2-MERCAPTOPYRIMIDINE
ethyl 3-(N-methylcyanamino)-2-butenoate

Downstream Product

1-(2-deoxy-β-D-erythro-pentofuranosyl)-2-thiouracil
2,4-Dichloropyrimidine
2,3,5,-Tri-O-benzoyl-2-thiouridine
thymine

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