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6-propyl-2-thiouracil

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Origin: China

Cas No: 51-52-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 51-52-5 Formula: C7H10N2OS Molecular Weight: 170.23200

Description

Propylthiouracil (PTU) or 6-n-propylthiouracil (PROP) is a thiouracil-derived drug used to treat hyperthyroidism (including Graves' disease) by decreasing the amount of thyroid hormone produced by the thyroid gland. Its notable side effects include a risk of agranulocytosis and aplastic anemia.
On 3 June 2009, the FDA published an alert "notifying healthcare professionals of the risk of serious liver injury, including liver failure and death, with the use of propylthiouracil." As a result, propylthiouracil is no longer recommended in non-pregnant adults and in children as the front line antithyroid medication.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Basic Info

Chemical Name	6-propyl-2-thiouracil
Synonyms	4(1H)-Pyrimidinone, 2,3-dihydro-6-propyl-2-thioxo-; Prothycil; 4-hydroxy-2-mercapto-6-propylpyrimidine; Propylthiouracil; 2,3-Dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone,4-Hydroxy-2-mercapto-6-propylpyrimidine; Thiuragyl; T 72; Protiural; PROTHYRAN; 6-Propyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; PROPACIL; PROIL; 6-Propyl-2-thiouracil; 2-Mercapto-6-Propylpyrimidin-4-ol; 6-n-propyl-2-thiouracil; PROPYCIL; 4-propyl-2-thiouracil; 6-n-propylthiouracil;
CAS No.	51-52-5
Molecular Formula	C7H10N2OS
Molecular Weight	170.23200
PSA	80.74000
LogP	1.38500

Properties

Appearance & Physical State	white to off-white crystalline powder
Density	1.24g/cm3
Boiling Point	355.2ºC at 760mmHg
Melting Point	218-221ºC
Flash Point	326ºC
Refractive Index	1.609
Water Solubility	1.1 g/L
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases. Light sensitive.
Storage Condition	Store in a cool, dry place. Keep container closed when not in use. Hormones and antibiotics room.

Safety Info

RTECS	YR1400000
Safety Statements	S36/37-S45
HS Code	2933599090
WGK Germany	3
Risk Statements	R22; R40
Hazard Codes	Xn

Synthesis Route

thiourea+Methyl 3-oxohexanoate→6-propyl-2-thiouracil
ethyl 3-oxohexanoate+thiourea→6-propyl-2-thiouracil

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	TDLo - Lowest published toxic dose	Human - man	42857 ug/kg/10D-I	1.Kidney, Ureter, Bladder-changes in tubules (including acute renal failure, acute tubular necrosis) 2.Kidney, Ureter, Bladder-interstitial nephritis 3.Kidney, Ureter, Bladder-urine volume decreased
Oral	LDLo - Lowest published lethal dose	Human - woman	480 mg/kg/9W-I	1.Vascular-other changes 2.Blood-agranulocytosis
Oral	TDLo - Lowest published toxic dose	Human - child	900 mg/kg/60D-I	1.Liver-hepatitis (hepatocellular necrosis), diffuse 2.Liver-jaundice, other or unclassified

Precursor

thiourea
Methyl 3-oxohexanoate
ethyl 3-oxohexanoate

Downstream Product

3-(5-nitropyridin-2-yl)-6-propyl-2-sulfanylidene-1H-pyrimidin-4-one
2-(5-nitropyridin-2-yl)sulfanyl-6-propyl-1H-pyrimidin-4-one
5-bromo-6-propyl-1H-pyrimidine-2,4-dione
1,3-dimethyl-6-propylpyrimidine-2,4-dione

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