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Thiamiprine

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Origin: China

Cas No: 5581-52-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 5581-52-2 Formula: C9H8N8O2S Molecular Weight: 292.27700

    Description

    An immunosuppressant. Antiarthritic.

    Basic Info

    Chemical Name Thiamiprine
    Synonyms

    6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purin-2-amine;

    CAS No. 5581-52-2
    Molecular Formula C9H8N8O2S
    Molecular Weight 292.27700
    PSA 169.42000
    LogP 1.83240

    Properties

    Density 2.05g/cm3
    Boiling Point 599.6ºC at 760mmHg
    Melting Point >200ºC (DEC.)
    Flash Point 316.4ºC
    Refractive Index 1.994

    Safety Info

    HS Code 2933990090

    Synthesis Route

    tioguanine+5-Chloro-1-methyl-4-nitroimidazole→Thiamiprine

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - mouse 450 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - mouse 136 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Oral TDLo - Lowest published toxic dose Rodent - rat 5040 mg/kg,male 4 week(s) pre-mating 1.Reproductive-Paternal Effects-testes, epididymis, sperm duct

    Precursor

    5-Chloro-1-methyl-4-nitroimidazole
    tioguanine

    Downstream Product

    9H-Purin-2-amine, 9-(2-deoxy-.β.-D-erythro-pentofuranosyl)-6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-
    9H-Purine, 2-amino-6-(1-methyl-4-nitroimidazol-5-ylthio)-9-.β.-D-ribofuranosyl-

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