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Picture of Theophylline-7-Acetic Acid

Theophylline-7-Acetic Acid

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Origin: China

Cas No: 652-37-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 652-37-9 Formula: C9H10N4O4 Molecular Weight: 238.20000

    Description

    Acefylline, also known as acetyloxytheophylline, is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation etanautine to help offset its stimulant effects.
    Theophyllines are classified in this group. Other respiratory stimulants are classified in R07AB - Respiratory stimulants.
    Corticosteroids for systemic use, see H02.
    Sympathomimetics for systemic treatment of rhinitis, see R01BA.
    This group comprises mainly the xanthines. The DDDs for these substances are based on treatment of obstructive lung diseases.
    A number of preparations containing e.g. theophylline are classified in this group even if they do not have asthma as an indication.
    Combinations of xanthines and other agents (except adrenergics, see R03DB - Xanthines and adrenergics) are classified at separate 5th levels using the corresponding 50-series (e.g. mucolytics).

    Basic Info

    Chemical Name Theophylline-7-Acetic Acid
    Synonyms

    2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetic acid;

    CAS No. 652-37-9
    Molecular Formula C9H10N4O4
    Molecular Weight 238.20000
    PSA 99.12000
    LogP -1.48170

    Properties

    Appearance & Physical State White Crystalline Solid
    Density 1.64 g/cm3
    Boiling Point 269-271ºC
    Melting Point 270-272ºC
    Flash Point 289.9ºC
    Storage Condition Refrigerator

    Safety Info

    RTECS UO7451300
    Safety Statements S26-S36
    WGK Germany 2
    Risk Statements R36/37/38
    Hazard Codes Xi

    Synthesis Route

    theophylline+chloroacetic acidTheophylline-7-Acetic Acid
    ethyl 2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetateTheophylline-7-Acetic Acid
    chloroacetic acidTheophylline-7-Acetic Acid

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat >5 gm/kg 1.Details of toxic effects not reported other than lethal dose value
    Intravenous LD50 - Lethal dose, 50 percent kill Rodent - rat >500 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Oral LD50 - Lethal dose, 50 percent kill Rodent - mouse 2733 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    ethyl 2-(1,3-dimethyl-2,6-dioxo-2,3-dihydro-1H-purin-7(6H)-yl)acetate
    theophylline
    chloroacetic acid

    Downstream Product

    1,3-dimethyl-7-(2-oxopropyl)purine-2,6-dione

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