Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> tert-butyl (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate

tert-butyl (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate

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Origin: China

Cas No: 134395-00-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
CAS No.:
134395-00-9
Other Names:
Atorvastatin tert-Butyl Ester
MF:
C37H43FN2O5
EINECS No.:
134395-00-9
Place of Origin:
China
Type:
Electrolyte Balance and Dialysis Agents, Vitamins, Amino Acids and Coenzymes
Grade Standard:
Feed Grade, Food Grade, Medicine Grade, Tech Grade
Usage:
Animal Pharmaceuticals
Brand Name:
Sincere-Chem
Model Number:
Sincere-Chem 134395-00-9
Purity:
97%
MW:
614.7461232
Melting point:
66-68°C
Color:
White Color
Appearance:
Off-white to pale yellow solid
Packaging&Delivery
Packaging Details
as customers requested;
Port
Qingdao Port, China; Shanghai port, China
Lead Time:
Quantity(Kilograms) 1 - 1 >1
Est. Time(days) 2 To be negotiated

Property

CAS No.: 134395-00-9 Formula: C37H43FN2O5 Molecular Weight: 614.74600

Description

An impurity arising in the synthesis of Atorvastatin.

Basic Info

Chemical Name	tert-butyl (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
Synonyms	tert-butyl (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]-3,5-dihydroxyheptanoate; (\|AR,\|AR)-2-(4-Fluorophenyl)-\|A,\|A-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid 1,1-Dimethylethyl Ester; Atorvastatin tert-Butyl Ester; (3R,5R)-tert-Butyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate;
CAS No.	134395-00-9
Molecular Formula	C37H43FN2O5
Molecular Weight	614.74600
PSA	100.79000
LogP	7.64370

Properties

Melting Point	66-68ºC

Safety Info

HS Code	2934999090

Synthesis Route

tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate→5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide+tert-butyl (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate→tert-butyl (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate→tert-butyl (3R,5R)-7-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate

Precursor

4-Fluorobenzaldehyde
tert-butyl 2-((2R,4R)-4-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-1,5-dioxaspiro[5.5]undecan-2-yl)acetate
(4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate

Downstream Product

5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide
Atorvastatin
Atorvastatin calcium
ATORVASTATIN SODIUM

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