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terbinafine hydrochloride

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Origin: China

Cas No: 78628-80-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Dermatologist Broad-spectrum Antifungal Drugs

    Terbinafine hydrochloride is a kind of broad-spectrum dermatologist allyl amine antifungal drugs.Approved by FDA of the United States for OTC drugs in 1996, and appeared in the market of the United States in the same year. At present, the drug is been sold in more than 90 countries of the word. It can specificity trouble the late biological decomposition of fungus sterol, selectively inhibit the activity of fungal squalene ring oxidase, and inhibit the squalene epoxidation in the formation of ungal cell membrane, thus to kill or inhibit the active of the fungus. Suitable for treatment of candidiasis skin, such as tinea manuum, tinea, tinea, ringworm of the body, tinea versicolor, it is also the best medicine for the treatment of onychomycosis.
    Terbinafine hydrochloride entered the the first batch of country announced OTC directory in 2000. This product belongs to antifungal drugs. It has strong effect on shallow fungal infection, and can cure most of the fungal skin diseases through external use.

     

    Indications

    1.Skin, hair and nail infection caused by Btrichophyta (white hair versicolor bacterium, Trichophyton mentagrophytes, Trichophyton verrucosum, trichophyton tonsurans and Trichophyton violaceum, etc.), microsporum canis, epidermophyton floccosum, ect.
    2.Skin yeast infections caused by all kinds of tinea disease (ringworm of the body, tinea, tinea manus and tinea capitis, etc.) and candida (candida albicans, etc.).
    3.Onychomycosis (nail fungus infection) caused by molds.

  •  

    Property

    CAS No.: 78628-80-5 Formula: C21H26ClN Molecular Weight: 327.89100
     

    Description

    Terbinafine hydrochloride, also known under the trade name Lamisil, is an antifungal developed by Novartis and Omega Pharma. It is highly hydrophobic and tends to accumulate in hair, skin, nails, and fatty tissue.
    It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.
     

    Basic Info

    Chemical Name terbinafine hydrochloride
    Synonyms

    Terbinafine hydrochloride;
    (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine monohydrochloride;

    CAS No. 78628-80-5
    Molecular Formula C21H26ClN
    Molecular Weight 327.89100
    PSA 3.24000
    LogP 5.67930
     

    Properties

    Appearance & Physical State Crystalline powder
    Density 1.007g/cm3
    Boiling Point 417.9ºC at 760 mmHg
    Melting Point 204-208ºC
    Flash Point 183.7ºC
    Refractive Index 1.586
    Storage Condition -20ºC Freezer
     

    Safety Info

    RTECS QJ8600100
    Safety Statements S26; S36/37/39; S61; S60
    HS Code 2921499090
    RIDADR UN 3077 9/PG 3
    Risk Statements R36/37/38
    Hazard Codes Xi; N
    Caution Statement P261; P273; P305 + P351 + P338; P501
    Signal Word Warning
    Hazard Declaration H315; H319; H335; H410
    Symbol GHS07, GHS09
     

    Synthesis Route

    1-Methyl-aminomethyl naphthalene+6,6-dimethylhept-1-en-4-yn-3-ol→terbinafine hydrochloride
    Terbinafine→terbinafine hydrochloride
    1-Chloro-6,6-dimethylhept-2-en-4-yne(cis+trans)+1-Methyl-aminomethyl naphthalene→terbinafine hydrochloride
     

    Precursor

    N-Methyl-1-naphthalenemethylamine hydrochloride
    1-Methyl-aminomethyl naphthalene
    Terbinafine
    1-Chloro-6,6-dimethylhept-2-en-4-yne(cis+trans)
     

    Downstream Product

    Terbinafine

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