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tazarotene

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Origin: China

Cas No: 118292-40-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 118292-40-3 Formula: C21H21NO2S Molecular Weight: 351.46200

Description

Tazarotene (marketed as Tazorac, Avage, Zorac, and Fabior) is a third-generation prescription topical retinoid sold as a cream, gel, or foam. Tazarotene is a member of the acetylenic class of retinoids. This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). It is commonly sold in two concentrations: 0.05% and 0.1%.

Basic Info

Chemical Name	tazarotene
Synonyms	Tazarotene; ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate; Ethyl 6-((4,4-dimethylthiochroman-6-yl)ethynyl)nicotinate;
CAS No.	118292-40-3
Molecular Formula	C21H21NO2S
Molecular Weight	351.46200
PSA	64.49000
LogP	4.43150

Properties

Appearance & Physical State	White Solid
Density	1.22 g/cm3
Boiling Point	499.8ºC at 760 mmHg
Melting Point	97-98ºC
Flash Point	256.1ºC
Refractive Index	1.624
Vapor Pressure	4.03E-10mmHg at 25°C

Safety Info

HS Code	2942000000

Synthesis Route

6-ethynyl-4,4-dimethyl-2,3-dihydrothiochromene+Ethyl 6-chloronicotinate→tazarotene
6-ethynyl-4,4-dimethyl-2,3-dihydrothiochromene→tazarotene
Ethanol+tazarotenic acid→tazarotene

Toxicity

Exposure Route	Type of Test	Species Observed	Dose/Duration	Toxic Effects
Oral	LD - Lethal dose	Rodent - rat	>2 gm/kg	1.Details of toxic effects not reported other than lethal dose value
Oral	TDLo - Lowest published toxic dose	Rodent - rat	22750 ug/kg/13W-I	1.Musculoskeletal-other changes
Oral	TDLo - Lowest published toxic dose	Primate - monkey	35 mg/kg/26W-I	1.Musculoskeletal-other changes