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tamsulosin

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Origin: China

Cas No: 106133-20-4

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Product Description

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CAS No.: 106133-20-4 Formula: C20H28N2O5S Molecular Weight: 408.51200

Description

Tamsulosin (rINN) (trade name Flomax) is an α1a adrenergic receptor antagonist used in the symptomatic treatment of benign prostatic hyperplasia (BPH). Tamsulosin was developed by Yamanouchi Pharmaceuticals (now part of Astellas Pharma) and was first marketed in 1996 as Flomax, and also under the name Omnic.
Tamsulosin is used in the treatment of difficult urination, a common symptom of enlarged prostate. Tamsulosin, and other medications in the class called alpha blockers, work by relaxing bladder neck muscles and muscle fibers in the prostate itself and make it easier to urinate.
The U.S. patent for Flomax expired in October 2009. The U.S. Food and Drug Administration (FDA) approved generic Flomax in March 2010.

Basic Info

Chemical Name	tamsulosin
Synonyms	Flomax; Tamsulosinum; 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide; [14C]-Tamsulosin; TAMSULOSIN; Tamsulosine; Tamsulosina; Tamsolusin; Tamsulosina [INN-Spanish]; Tamsulosine [INN-French]; (R)-(-)-5-[2-(2-(2-ethoxyphenoxy)ethylamino)propyl]-2-methoxybenzenesulfonamide; Tamsulosinum [INN-Latin];
CAS No.	106133-20-4
Molecular Formula	C20H28N2O5S
Molecular Weight	408.51200
PSA	108.26000
LogP	4.51290

Properties

Appearance & Physical State	White crystals
Density	1.191 g/cm3
Boiling Point	595.5ºC at 760 mmHg
Melting Point	226-228ºC
Flash Point	313.9ºC
Refractive Index	1.553
Vapor Pressure	3.79E-14mmHg at 25°C

Safety Info

HS Code	2935009090

Synthesis Route

5-(2-((2-(2-ethoxyphenoxy)ethyl)imino)propyl)-2-methoxybenzenesulfonamide→tamsulosin hydrochloride+tamsulosin
(R)-2-(2-ethoxyphenoxy)-N-[2-(4-methoxy-3-aminosulfonyl-phenyl)-1-methyl-ethyl]-acetamide→tamsulosin
N,N-dimethylformamide→tamsulosin

Precursor

N,N-dimethylformamide
5-(2-((2-(2-ethoxyphenoxy)ethyl)imino)propyl)-2-methoxybenzenesulfonamide
tamsulosin
(S)-5-(2-hydroxypropyl)-2-methoxybenzenesulfonamide

Downstream Product

tamsulosin

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