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tamoxifen

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Origin: China

Cas No: 10540-29-1

Specification: 99%min

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Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 10540-29-1 Formula: C26H29NO Molecular Weight: 371.51500

    Description

    Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells. Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.

    Basic Info

    Chemical Name tamoxifen
    Synonyms

    trans-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine;
    Tamoxifene;
    [3H]-Tamoxifen;
    Tamoxen;
    Tamoxifen;
    Valodex;
    2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine;
    Oncomox;
    Citofen;
    Diemon;
    Soltamox;
    Crisafeno;
    (Z)-1-{4-[2-(dimethylamino)ethoxy]-phenyl}-1,2-diphenyl-1-butene;
    [14C]-Tamoxifen;
    Tamizam;

    CAS No. 10540-29-1
    Molecular Formula C26H29NO
    Molecular Weight 371.51500
    PSA 12.47000
    LogP 5.99610

    Properties

    Appearance & Physical State fine off-white crystalline powder
    Density 1.042 g/cm3
    Melting Point 97-98ºC
    Flash Point 140ºC
    Refractive Index 1.582
    Storage Condition 2-8ºC
    Vapor Pressure 1.85E-09mmHg at 25°C

    Safety Info

    RTECS KR5919600
    Safety Statements S53-S45
    HS Code 2922199090
    WGK Germany 3
    Risk Statements R45; R60; R61; R64
    Hazard Codes T
    Caution Statement P201; P263; P308 + P313
    Symbol GHS08
    Signal Word Danger
    Hazard Declaration H350; H360; H362

    Synthesis Route

    (E)-1-(4',4',5',5'-tetramethyl-1',3',2'-dioxaborolan-2'-yl)-1,2-diphenyl-1-butene+2-(4-iodophenoxy)-N,N-dimethylethanamine→tamoxifen
    (Z)-2-(4-(1,2-diphenylbuta-1,3-dien-1-yl)phenoxy)-N,N-dimethylethanamine→tamoxifen
    Iodobenzene+1-PHENYL-1-BUTYNE→tamoxifen+[2-(BIPHENYL-4-YLOXY)-ETHYL]-DIMETHYL-AMINE

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral TDLo - Lowest published toxic dose Human - woman 5600 ug/kg/1W-I 1.Skin and Appendages-breast
    Unreported TDLo - Lowest published toxic dose Human - woman 200 ug/kg/D 1.Gastrointestinal-nausea or vomiting
    2.Blood-leukopenia
    3.Blood-thrombocytopenia
    Unreported TDLo - Lowest published toxic dose Human - woman 5600 ug/kg/2W-I 1.Blood-normocytic anemia
    2.Musculoskeletal-joints

    Precursor

    1-PHENYL-1-BUTYNE
    (Z)-2-(4-(1,2-diphenylbuta-1,3-dien-1-yl)phenoxy)-N,N-dimethylethanamine
    Iodobenzene
    (E)-1-(4',4',5',5'-tetramethyl-1',3',2'-dioxaborolan-2'-yl)-1,2-diphenyl-1-butene

    Downstream Product

    2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]ethyl-trimethylazanium,iodide
    afimoxifene
    tamoxifen citrate
    2-[4-[(1R,2R)-1,2-diphenylbutyl]phenoxy]-N,N-dimethylethanamine

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