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sildenafil

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Origin: China

Cas No: 139755-83-2

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Standard:

    EP
    CAS NO.: 171599-83-0
    Molecular formula：

    C28H38N6O11S
    Structural formula：

    Loss on Dry: Not more than 2.5%
    Assay: Min 99%
    Description:  

    Used to treat erectile dysfunction and pulmonary arterial hypertension
  •  

    Property

    CAS No.: 139755-83-2 Formula: C22H30N6O4S Molecular Weight: 474.57600
     

    Description

    An orally active selective type 5 cGMP phosphodiesterase inhibitor.
     

    Basic Info

    Chemical Name sildenafil
    Synonyms

    SIDANAFIL;
    viagTa;
    Revatio;
    Sildenafil;

    CAS No. 139755-83-2
    Molecular Formula C22H30N6O4S
    Molecular Weight 474.57600
    PSA 121.80000
    LogP 2.56750
     

    Properties

    Appearance & Physical State White crystalline powder
    Density 1.39g/cm3
    Boiling Point 672.4ºC at 760 mmHg
    Melting Point 187-189ºC
    Flash Point 360.5ºC
    Refractive Index 1.664
    Storage Condition Store in original container in a cool dark place.
    Vapor Pressure 6.1E-18mmHg at 25°C
     

    Safety Info

    Safety Statements S22; S24/25; S36; S26
    HS Code 2933990090
    Risk Statements R36/37/38
    Hazard Codes Xi
     

    Synthesis Route

    7-chloro-5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propylpyrazolo[4,3-d]pyrimidine→sildenafil
    1-Methylpiperazine+4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonyl chloride→sildenafil
    5-[2-ethoxycarbonyloxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one+Ethanol→sildenafil
     

    Precursor

    Ethanol
    1-Methylpiperazine
    7-chloro-5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propylpyrazolo[4,3-d]pyrimidine
    4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzenesulfonyl chloride

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