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Scopolamine

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Origin: China

Cas No: 51-34-3

Specification: 99%min

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 51-34-3 Formula: C17H21NO4 Molecular Weight: 303.35300

    Description

    Hyoscine hydrobromide, also known as scopolamine hydrobromide, is a medication used in the treatment of motion sickness and postoperative nausea and vomiting.
    One common side effect is drowsiness. Scopolamine is a tropane alkaloid drug with muscarinic antagonist effects. Hyoscine hydrobromide exerts its effects by acting as a competitive antagonist at muscarinic acetylcholine receptors; it is thus classified as an anticholinergic, antimuscarinic drug. Although it is usually referred to as a nonspecific antagonist, there is indirect evidence for m1-receptor subtype specificity.
    It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. Scopolamine is named after the plant genus Scopolia. The name "hyoscine" is from the scientific name for henbane, Hyoscyamus niger.

    Basic Info

    Chemical Name Scopolamine
    Synonyms

    Hyoscine;
    Benzeneacetic acid, α-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl ester, [(7S)-(1α,2β,4β,5α,7β)]-;
    Scopadulcic acid B;
    (−)-Scopolamine;
    (1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]nonan-7-yl (S)-3-hydroxy-2-phenylpropanoate;
    Scopoderm TTS;

    CAS No. 51-34-3
    Molecular Formula C17H21NO4
    Molecular Weight 303.35300
    PSA 62.30000
    LogP 0.85600

    Properties

    Appearance & Physical State White crystalline powder
    Density 1.31
    Boiling Point 460.3ºC at 760 mmHg
    Melting Point 59 ºC
    Flash Point 232.2ºC

    Safety Info

    Safety Statements S25; S45
    Risk Statements R26/27/28
    Hazard Codes T+

    Synthesis Route

    6,7-dehydro-3-tropoyloxytropane→Scopolamine
    [(3S,5S,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenylpropanoate→Scopolamine
    Tersigat→(-)-N-Ethylnorscopolamin+Scopolamine

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Subcutaneous TDLo - Lowest published toxic dose Human 2 ug/kg 1.Brain and Coverings-changes in surface EEG
    2.Behavioral-hallucinations, distorted perceptions
    3.Behavioral-excitement
    Subcutaneous TDLo - Lowest published toxic dose Human - man 14 ug/kg 1.Behavioral-hallucinations, distorted perceptions
    2.Behavioral-ataxia
    Subcutaneous TDLo - Lowest published toxic dose Human - woman 13 ug/kg 1.Behavioral-hallucinations, distorted perceptions
    2.Behavioral-ataxia

    Precursor

    6,7-dehydro-3-tropoyloxytropane
    [(3S,5S,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenylpropanoate
    Tersigat

    Downstream Product

    Scopoline
    (1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol
    tropate
    [(3S,5S,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] (2S)-3-hydroxy-2-phenylpropanoate

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