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(S)-timolol maleate

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Origin: China

Cas No: 26921-17-5

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    26921-17-5
    Other Names:
    Timolol maleate
    MF:
    C43H53NO14
    EINECS No.:
    601-339-2
    Place of Origin:
    Hebei, China
    Type:
    Auxiliaries and Other Medicinal Chemicals
    Grade Standard:
    Medicine Grade
    Brand Name:
    Crovell
    Model Number:
    Crovell 26921-17-5
    Purity:
    99%
    Molecular Weight:
    432.49 Timolol maleate CAS 26921-17-5
    Melting point:
    202-203 °C(lit.) Timolol maleate CAS 26921-17-5
    Boiling point:
    Timolol maleate CAS 26921-17-5
    Density:
    Timolol maleate CAS 26921-17-5
    Refractive index:
    Timolol maleate CAS 26921-17-5
    Flash point:
    Timolol maleate CAS 26921-17-5

    Packaging&Delivery

    Packaging Details
    25kg/drum or as request
    Lead Time:
    Quantity(Kilograms)1 - 100101 - 1000>1000
    Est. Time(days)37To be negotiated

    Products Description

    Packaging
    Size
    25kg/Drum/Bag
    Weight
    Above 25kg



    Packaging Details
    The packing of small quantity or sample is foil bag.And the packing of large quantity is 25kg/drum or as customers' request.
    About delivery we suggest by express if quantity is small.500kg or above 500kg we suugest by air or by sea.Anyway we will according customers' requirement.

  • Property

    CAS No.: 26921-17-5 Formula: C17H28N4O7S Molecular Weight: 432.49200

    Description

    Antihypertensive; antiarrhythmic (class II); antianginal; antiglaucoma agent.

    Basic Info

    Chemical Name (S)-timolol maleate
    Synonyms

    Timolol maleate salt;
    (S)-Timolol maleate;
    Timolol maleate;
    (S)-(-)-Timolol Maleate;

    CAS No. 26921-17-5
    Molecular Formula C17H28N4O7S
    Molecular Weight 432.49200
    PSA 182.58000
    LogP 0.67020

    Properties

    Boiling Point 704.6ºC at 760 mmHg
    Melting Point 202-203ºC(lit.)
    Flash Point 380ºC
    Vapor Pressure 7.7E-21mmHg at 25°C

    Safety Info

    RTECS UA8475000
    Safety Statements S26; S36/37/39
    HS Code 2934999090
    WGK Germany 3
    Risk Statements R22
    Hazard Codes Xn; Xi

    Synthesis Route

    3-Hydroxy-4-morpholino-1,2,5-thiazole→(S)-timolol maleate
    rac 4-[4-(Oxiranylmethoxy)-1,2,5-thiadiazol-3-yl]morpholine→(S)-timolol maleate
    (S)-5-((4-morpholino-1,2,5-thiadiazol-3-yloxy)-methyl)-3-tert-butyloxazolidin-2-one→(S)-timolol maleate

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Ocular TDLo - Lowest published toxic dose Human - man 39 mg/kg/87W-I 1.Behavioral-convulsions or effect on seizure threshold
    Ocular LDLo - Lowest published lethal dose Human - woman 5 ug/kg 1.Cardiac-other changes
    2.Lungs, Thorax, or Respiration-structural or functional change in trachea or bronchi
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 1028 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    (S)-5-((4-morpholino-1,2,5-thiadiazol-3-yloxy)-methyl)-3-tert-butyloxazolidin-2-one
    3-Chloro-4-morpholino-1,2,5-thiadiazole
    3-Hydroxy-4-morpholino-1,2,5-thiazole
    rac 4-[4-(Oxiranylmethoxy)-1,2,5-thiadiazol-3-yl]morpholine

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