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(S)-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinenitrile

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Origin: China

Cas No: 1564265-94-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 1564265-94-6 Formula: C18H25N3O2 Molecular Weight: 315.41000

Description

(2’S,2R,cis)-Saxagliptin is an impurity of Saxagliptin; a potent and selective reversible inhibitor of dipeptidyl peptidase-4 (DPP-IV) developed for the treatment of type 2 diabetes.

Basic Info

Chemical Name	(S)-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinenitrile
Synonyms
CAS No.	1564265-94-6
Molecular Formula	C18H25N3O2
Molecular Weight	315.41000
PSA	90.35000
LogP	1.79618

Properties

Melting Point	99 - 102 °C

Synthesis Route

Boc-D-5-hydroxyproline ethyl ester→(S)-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinenitrile
→(S)-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinenitrile
1-tert-butyl 2-ethyl (2R)-2,3-dihydro-1H-pyrrole-1,2-dicarboxylate→(S)-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinenitrile

Precursor

1-tert-butyl 2-ethyl (2R)-2,3-dihydro-1H-pyrrole-1,2-dicarboxylate

Boc-D-5-hydroxyproline ethyl ester

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