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(S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol

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Origin: China

Cas No: 209414-27-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 209414-27-7 Formula: C13H11ClF3NO Molecular Weight: 289.68100

Description

Intermediate in the preparation of Efavirenz impurity.

Basic Info

Chemical Name	(S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol
Synonyms	Efavirenz Related CoMpound A;
CAS No.	209414-27-7
Molecular Formula	C13H11ClF3NO
Molecular Weight	289.68100
PSA	46.25000
LogP	3.66670

Properties

Density	1.46
Boiling Point	425.052ºC at 760 mmHg
Refractive Index	1.575
Vapor Pressure	0mmHg at 25°C

Safety Info

HS Code	2922199090

Synthesis Route

Cyclopropyl acetylene+4-Chloro-2-trifluoroacetylaniline→(S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol
4-Chloro-2-trifluoroacetylaniline+magnesium,ethynylcyclopropane,chloride→(S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol
5-Chloro-1-pentyne+4-Chloro-2-trifluoroacetylaniline→(S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol

Precursor

5-Chloro-1-pentyne
Cyclopropyl acetylene
5-Chloro-α-(cyclopropylethynyl)-2-(triphenylmethyl)-amino-α-(trifluoromethyl) benzenemethanol
magnesium,ethynylcyclopropane,chloride

Downstream Product

ent-Efavirenz
efavirenz
[4-Chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl)phenyl]carbamic Acid Methyl Ester

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