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quinapril hydrochloride

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Origin: China

Cas No: 82586-55-8

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 82586-55-8 Formula: C25H31ClN2O5 Molecular Weight: 474.97700

    Description

    Quinapril is an angiotensin converting enzyme (ACE) inhibitor. Antihypertensive.

    Basic Info

    Chemical Name quinapril hydrochloride
    Synonyms

    Acuitel;
    ccupril;
    Acequin;
    quinapril HCl;
    2-<<1-ethoxycarbonyl)-3-phenylpropyl>amino>-1-oxopropyl>-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid monohydrochloride;
    Conan;
    ACCUPRIN;
    Quinapril hydrochloride;
    Acupril;
    CI-906;
    Acuprel;
    ACCUPRO;
    Korec;
    Quinapril (hydrochloride);

    CAS No. 82586-55-8
    Molecular Formula C25H31ClN2O5
    Molecular Weight 474.97700
    PSA 95.94000
    LogP 3.69790

    Properties

    Appearance & Physical State white crystalline solid
    Boiling Point 662ºC at 760 mmHg
    Melting Point 120-130ºC
    Flash Point 354.1ºC
    Storage Condition 2-8ºC

    Safety Info

    Safety Statements S22; S24/25

    Synthesis Route

    ethyl 2-[(1-isoquinolin-2-ium-2-yl-1-oxopropan-2-yl)amino]-4-phenylbutanoate→quinapril hydrochloride
    (1S,2S,3S)-2-[2-(1-ethoxycarbonyl-3-phenyl-propylamino)-propionyl] -1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid tert-butyl ester→quinapril hydrochloride+Isobutene

    Precursor

    (1S,2S,3S)-2-[2-(1-ethoxycarbonyl-3-phenyl-propylamino)-propionyl] -1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid tert-butyl ester
    ethyl 2-[(1-isoquinolin-2-ium-2-yl-1-oxopropan-2-yl)amino]-4-phenylbutanoate

    Downstream Product

    quinapril
    QUINAPRILAT HYDRATE
    Ethyl (3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenyl-2-butanyl]-L-alanyl }-1,2,3,4-tetrahydro-3-isoquinolinecarboxylate
    Quinapril Diketopiperazine

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