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Prostaglandin F2α methyl ester

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Origin: China

Cas No: 33854-16-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 33854-16-9 Formula: C21H36O5 Molecular Weight: 368.50800

    Basic Info

    Chemical Name Prostaglandin F2α methyl ester
    Synonyms

    PROSTAGLANDINS F2ALPHA METHYL ESTER;

    CAS No. 33854-16-9
    Molecular Formula C21H36O5
    Molecular Weight 368.50800
    PSA 86.99000
    LogP 3.13130

    Properties

    Density 1.095g/cm3
    Boiling Point 506ºC at 760 mmHg
    Flash Point -9ºC
    Refractive Index 1.543
    Storage Condition -20ºC

    Safety Info

    RIDADR UN 1231 3/PG 2
    Risk Statements R11; R36; R66; R67
    Hazard Codes F; Xi

    Synthesis Route

    methyl (Z)-7-[(1R,4S,5R,6R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-2,3-dioxabicyclo[2.2.1]heptan-6-yl]hept-5-enoate→Prostaglandin F2α methyl ester+Prostaglandin D2 methyl ester
    11,15-O-bis(tert-butyldimethylsilyl)PGF2α methyl ester→Prostaglandin F2α methyl ester
    (4R)-(+)-T-BUTYLDIMETHYLSILOXY-2-CYCLOPENTEN-1-ONE→Prostaglandin F2α methyl ester

    Precursor

    (1E,3S)-3-t-butyldimethylsilyloxy-1-lithio-octane
    11,15-O-bis(tert-butyldimethylsilyl)PGF2α methyl ester
    5,6-Didehydro-11,15-O-bis(tert-butyldimethylsilyl)PGE2 methyl ester
    methyl (Z)-7-[(1R,4S,5R,6R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-2,3-dioxabicyclo[2.2.1]heptan-6-yl]hept-5-enoate

    Downstream Product

    7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3S)-3-hydroxyoctyl]cyclopentyl]heptanoic acid
    prostaglandin D2
    sodium,(5R)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(Z,3S)-3-hydroxyoct-1-enyl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-3-yl]-5-fluoropentanoate
    methyl 6,9α-epoxy-5(S)-fluoro-11α,15(S)-dihydroxyprosta-6,13(E)-dien-1-oate

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