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prostaglandin A2

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Origin: China

Cas No: 13345-50-1

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

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Products Specification
Product Description

Property

CAS No.: 13345-50-1 Formula: C20H30O4 Molecular Weight: 334.45000

Description

Prostaglandin A2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. Prostaglandin A2 is generally not present in mammals. Prostaglandin A2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity. Prostaglandin A2 has also been shown to act as a vasodilator with natriuretic properties.

Basic Info

Chemical Name	prostaglandin A2
Synonyms	PROSTAGLANDIN A2; PROSTAGLANDINS A2; Prostaglandin A; Prostaglandin A2 solution; PGA2; MEDULLIN;
CAS No.	13345-50-1
Molecular Formula	C20H30O4
Molecular Weight	334.45000
PSA	74.60000
LogP	4.05630

Properties

Density	1.103g/cm3
Boiling Point	515.3ºC at 760mmHg
Flash Point	279.6ºC
Refractive Index	1.555
Storage Condition	-20ºC
Vapor Pressure	8.93E-13mmHg at 25°C

Safety Info

RIDADR	UN 1231 3/PG 2
Risk Statements	R11
Hazard Codes	F; Xi

Synthesis Route

Bis(tert-butyldimethylsilyl)-PGE2 oxime→prostaglandin A2+prostaglandin E2
(Z)-7-{(1R,2S)-2-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-5-oxo-cyclopent-3-enyl}-hept-5-enoic acid→prostaglandin A2
(Z)-7-((1S,2S,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)oct-1-en-1-yl)-5-((2-hydroxy-2-methylpropyl)amino)-1-(phenylsulfonyl)cyclopentyl)hept-5-enoic acid→prostaglandin A2

Precursor

Bis(tert-butyldimethylsilyl)-PGE2 oxime
Methyl (5Z,13E,8R,9S,11R,12S,15S)-11,15-Bis(tert-butyldimethylsiloxy)-9-(methylamino)-8-(phenylsulfonyl)-5,13-prostadienoate
(Z)-7-{(1R,2S)-2-[(E)-(S)-3-(tert-Butyl-diphenyl-silanyloxy)-oct-1-enyl]-5-oxo-cyclopent-3-enyl}-hept-5-enoic acid
(Z)-7-((1S,2S,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)oct-1-en-1-yl)-5-((2-hydroxy-2-methylpropyl)amino)-1-(phenylsulfonyl)cyclopentyl)hept-5-enoic acid

Downstream Product

prostaglandin F2α
Prostaglandin F2α methyl ester
methyl 7-[2-(3-hydroxyoct-1-enyl)-5-oxocyclopent-3-en-1-yl]hept-5-enoate
prostaglandin B2

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