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phenylmethanesulfonyl fluoride

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Origin: China

Cas No: 329-98-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Quick Details
Classification:
Halide (Except Chloride)
Type:
Sodium Fluoride
CAS No.:
329-98-6
Other Names:
PMSF
MF:
C7H7FO2S
EINECS No.:
206-350-2
Place of Origin:
Shandong, China
Grade Standard:
Medicine Grade
Purity:
99% Min
Appearance:
White Powder
Application:
Small molecule inhibitors
Brand Name:
HAIHANG
Model Number:
HH026
Color:
white to creamy solid
Name:
PMSF
Melting point:
92-95 °C
Density:
0.797 g/mL at 20 °C
Molecular Weight:
174.19
Usage:
Small molecule inhibitors
Molecular Formula:
C7H7FO2S
PSA:
42.52000
logP:
2.56670
Product Name:
Hot sale Phenylmethylsulfonyl fluoride 329-98-6
Packaging&Delivery
Packaging Details
Standard packing for Hot sale Phenylmethylsulfonyl fluoride 329-98-6
Port
Shanghai port,China

Property

CAS No.: 329-98-6 Formula: C7H7FO2S Molecular Weight: 174.19300

Description

In biochemistry, phenylmethane sulfonyl fluoride or phenylmethylsulfonyl fluoride (PMSF) is a serine protease inhibitor commonly used in the preparation of cell lysates. PMSF does not inhibit all serine proteases. It is rapidly degraded in water and stock solutions are usually made up in anhydrous ethanol, isopropanol, corn oil, or DMSO. Proteolytic inhibition occurs when a concentration between 0.1 - 1 mM PMSF is used. The half-life is short in aqueous solutions (110 min at pH 7, 55 min at pH 7.5, and 35 min at pH 8, all at 25°C).
PMSF binds specifically to the active site serine residue in a serine protease. It does not bind to any other serine residues in the protein. This is a result of the hyperactivity of that serine residue caused by the specific environmental conditions in the enzyme's active site. Because PMSF binds covalently to the enzyme, the complex can be viewed by X-ray crystallography; it can therefore be used as a chemical label to identify an essential active site serine in an enzyme.
The median lethal dose is less than 500mg/kg. PMSF is a cytotoxic chemical which should be handled only inside a fume hood.
PMSF is commonly used in protein solublization in order to deactivate proteases from digesting proteins of interest after cell lysis.

Basic Info

Chemical Name	phenylmethanesulfonyl fluoride
Synonyms	phenyl methane sulfonyl fluoride; Phenylmethanesulfonyl fluoride (PMSF); Benzylsulfonyl fluoride; Benzylsulphonyl fluoride; PMSF; Phenylmethylsulfonyl Fluoride; Phenylmethanesulfonyl fluoride; phenylmethyl-sulfonyl fluoride; Benzenemethanesulfonyl fluoride;
CAS No.	329-98-6
Molecular Formula	C7H7FO2S
Molecular Weight	174.19300
PSA	42.52000
LogP	2.56670

Properties

Appearance & Physical State	White to cream solid
Density	1.317 g/cm3
Boiling Point	285.7ºC at 760 mmHg
Melting Point	90-94ºC
Flash Point	126.6ºC
Refractive Index	1.502
Water Solubility	hydrolysis
Stability	Stable under normal temperatures and pressures.
Storage Condition	2-8ºC

Safety Info

RTECS	XT8050000
Hazard Class	8
Safety Statements	S26-S28-S36/37/39-S45
HS Code	2904909090
Packing Group	III
WGK Germany	3
RIDADR	UN 3261
Risk Statements	R25; R34
Hazard Codes	T
Signal Word	Danger
Caution Statement	P260; P280; P301 + P310 + P330; P303 + P361 + P353; P304 + P340 + P310; P305 + P351 + P338 + P310
Symbol	GHS05, GHS06
Hazard Declaration	H301; H314

Synthesis Route

dibenzyl disulfide→phenylmethanesulfonyl fluoride
dibenzyl disulfide→phenylmethanesulfonyl fluoride+benzylsulfonylsulfanylmethylbenzene
benzylsulfonylsulfanylmethylbenzene→phenylmethanesulfonyl fluoride

Precursor

benzylsulfonylsulfanylmethylbenzene
dibenzyl disulfide

Downstream Product

Cinnamonitrile
trans-chalcone
6-morpholin-4-yl-7-phenyl-8λ<sup>6</sup>-thiabicyclo[4.2.0]octane 8,8-dioxide
1,2-Diphenyl-vinyl-benzylsulfon

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