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phenylephrine hydrochloride

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Origin: China

Cas No: 61-76-7

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Quick Details

    CAS No.:
    61-76-7
    Other Names:
    Phenylephrine HCL
    MF:
    C9H14ClNO2
    EINECS No.:
    200-517-3
    Place of Origin:
    Jiangsu, China
    Type:
    Pharmaceutical Intermediates
    Purity:
    99%
    Brand Name:
    JUMING
    Model Number:
    CAS 61-76-7
    Application:
    Pharmaceutical intermediate
    Appearance:
    White Powder
    Sample:
    Available
    Molecular Weight:
    203.66600
    Packing:
    25kg/Bag
    Storage:
    Cool and dry place
    Boiling point:
    341.1 C at 760 mmHg
    Melting point:
    143-145 C(lit.)
    Flash point:
    163.4 C

    Packaging&Delivery

    Packaging Details
    25kg/Bag
    Pallet can be avialable for bulk order.
    Port
    SHANGHAI
    Lead Time:
    Quantity(Kilograms)1 - 1000>1000
    Est. Time(days)15To be negotiated
  • Property

    CAS No.: 61-76-7 Formula: C9H14ClNO2 Molecular Weight: 203.66600

    Description

    Phenylephrine is a selective α1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Phenylephrine is marketed as an alternative for the decongestant pseudoephedrine, although clinical trials show phenylephrine, taken orally at the recommended dose, to be no more effective than placebo. Phenylephrine can also cause a decrease in heart rate through reflex bradycardia.

    Basic Info

    Chemical Name phenylephrine hydrochloride
    Synonyms

    consdrin;
    (R)-(-)-Phenylephrine (hydrochloride);
    almefrin;
    synasal;
    Phenylephrine hydrochloride;
    efricel;
    phenylephrine HCl;
    lexatol;
    uri;
    metaoxedrin;
    fenox;
    emagrin;
    fenilfar;
    rhinall;

    CAS No. 61-76-7
    Molecular Formula C9H14ClNO2
    Molecular Weight 203.66600
    PSA 52.49000
    LogP 1.83790

    Properties

    Appearance & Physical State white to almost white crystalline powder
    Boiling Point 341.1ºC at 760 mmHg
    Melting Point 140-145ºC
    Flash Point 163.4ºC
    Refractive Index -45.5 ° (C=1, H2O)
    Water Solubility >=10 g/100 mL at 21 ºC
    Storage Condition Desiccate at RT

    Safety Info

    RTECS DO7525000
    Hazard Class 6.1(b)
    Safety Statements S26-S37/39
    HS Code 2937229000
    Packing Group III
    WGK Germany 3
    RIDADR UN 3249
    Risk Statements R22; R36/37/38
    Hazard Codes Xn

    Synthesis Route

    1-(3-hydroxyphenyl)-2-(methylamino)ethanone,hydrochloridephenylephrine hydrochloride
    phenylephrinephenylephrine hydrochloride
    1-(3-hydroxyphenyl)-2-(methylamino)ethanone,hydrochloridephenylephrine hydrochloride+3-[1-Hydroxy-2-(methylamino)ethyl]phenol hydrochloride (1:1)

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Ocular TDLo - Lowest published toxic dose Human - man 120 mg/kg 1.Brain and Coverings-changes in circulation (hemorrhage, thrombosis, etc.)
    2.Behavioral-muscle weakness
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat 350 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat 17 mg/kg 1.Details of toxic effects not reported other than lethal dose value

    Precursor

    phenylephrine
    (S)-2-(benzyl(methyl)amino)-1-(3-(benzyloxy)phenyl)ethanol hydrochloride
    (R)-3-(1-hydroxy-2-iodoethyl)phenol
    1-(3-hydroxyphenyl)-2-(methylamino)ethanone,hydrochloride

    Downstream Product

    DL-Phenylephrine Hydrochloride
    (R)-5-(3-Hydroxyphenyl)-3-methyl-2-oxazolidinone

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