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Nomegestrol acetate

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Origin: China

Cas No: 58652-20-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 58652-20-3 Formula: C23H30O4 Molecular Weight: 370.48200

    Description

    Nomegestrol acetate (INN) (brand name Lutenyl), or 19-normegestrol acetate, is a steroidal progestin with additional antigonadotropic effects which was introduced in 1986 and is used as a hormonal contraceptive. Unlike many other steroidal progestogens, it is selective for the progesterone receptor, lacking any significant affinity for other steroid receptors such as the androgen, estrogen, glucocorticoid, and mineralocorticoid receptors. As a result, it does not possess any androgenic, estrogenic, glucocorticoid, or mineralocorticoid effects. However, at sufficiently high doses it does have potent antiestrogenic and antiandrogenic effects due to its progesterone receptor-mediated antigonadotropic properties. Nomegestol acetate does have some direct antiandrogen action, but its affinity for the androgen receptor is 20-fold less than that of cyproterone acetate. The combination with estradiol is also used as a hormonal contraceptive and approved in Europe under the name Zoely.

    Basic Info

    Chemical Name Nomegestrol acetate
    Synonyms

    [(8S,9S,10R,13S,14S,17R)-17-acetyl-6,13-dimethyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate;

    CAS No. 58652-20-3
    Molecular Formula C23H30O4
    Molecular Weight 370.48200
    PSA 60.44000
    LogP 4.18520

    Properties

    Density 1.16 g/cm3
    Boiling Point 507.3ºC at 760 mmHg
    Flash Point 219.8ºC
    Refractive Index 1.554

    Safety Info

    Hazard Declaration H361fd; H400
    Symbol GHS08, GHS09
    Caution Statement P273; P281
    Signal Word Warning

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral TDLo - Lowest published toxic dose Human - woman 1050 ug/kg/21D-I 1.Endocrine-changes in luteinizing hormone
    2.Endocrine-estrogenic
    3.Endocrine-effect on menstrual cycle
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat >2 gm/kg 1.Details of toxic effects not reported other than lethal dose value
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat >2 gm/kg 1.Details of toxic effects not reported other than lethal dose value

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