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nitrofurantoin

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Origin: China

Cas No: 67-20-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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CAS No.: 67-20-9 Formula: C8H6N4O5 Molecular Weight: 238.15700

Description

Nitrofurantoin, sold under the trade name Macrobid among others, is an antibiotic used to treat bladder infections. It is not effective for kidney infections. It is taken by mouth.
Common side effects include nausea, loss of appetite, diarrhea, and headaches. Rarely numbness, lung problems, or liver problems may occur. It should not be used in people with kidney problems. While it looks like it is generally safe during pregnancy it should not be used near delivery. It works by slowing growth rather than killing bacteria.
Nitrofurantoin was first sold in 1953. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. The wholesale cost in the developing world is 0.005 and 0.46 USD a dose. In the United States it is about 60 USD for 10 days of treatment.

Basic Info

Chemical Name	nitrofurantoin
Synonyms	Furadantine; Nitrofuradantin; Nitrofurantoine; Furadonine; Macrodantin; Furadoine; 2,4-Imidazolidinedione, 1-[[(5-nitro-2-furanyl)methylene]amino]-; 5-Nitrofurantoin; Nitrofurantoina; 1-[(E)-(5-nitrofuran-2-yl)methylideneamino]imidazolidine-2,4-dione;
CAS No.	67-20-9
Molecular Formula	C8H6N4O5
Molecular Weight	238.15700
PSA	120.73000
LogP	0.86340

Properties

Appearance & Physical State	lemon yellow crystalline powder
Density	0.915 g/cm3 (20ºC)
Melting Point	268ºC
Refractive Index	1.52 (20ºC)
Stability	Stability Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents, strong alkalies, strong acids. Decomposes upon contact with most metals other than stainless steel and aluminium.
Storage Condition	0-6ºC

Safety Info

RTECS	MU2800000
Hazard Class	6.1(b)
Safety Statements	S22-S36/37-S45
HS Code	2933990090
WGK Germany	3
Packing Group	III
RIDADR	UN 2811
Risk Statements	R22; R42/43
Hazard Codes	Xn
Hazard Declaration	H302; H317; H334
Caution Statement	P261; P280; P342 + P311
Symbol	GHS07, GHS08
Signal Word	Danger

Synthesis Route

2-[carbamoyl-[(5-nitrofuran-2-yl)methylideneamino]amino]acetic acid→nitrofurantoin
5-Nitrofurfural→nitrofurantoin
1-aminoimidazolidine-2,4-dione+(5-Nitrofuran-2-yl)methylene diacetate→nitrofurantoin

Precursor

(5-Nitrofuran-2-yl)methylene diacetate
5-Nitrofurfural
2-[carbamoyl-[(5-nitrofuran-2-yl)methylideneamino]amino]acetic acid
1-aminoimidazolidine-2,4-dione

Downstream Product

1-aminoimidazolidine-2,4-dione
2-[carbamoyl-[(5-nitrofuran-2-yl)methylideneamino]amino]acetic acid

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