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N-Desmethyl Galanthamine

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Origin: China

Cas No: 41303-74-6

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 41303-74-6 Formula: C16H19NO3 Molecular Weight: 273.32700

    Description

    A metabolite of Galanthamine, a selective acetylcholinesterase inhibitor.

    Basic Info

    Chemical Name N-Desmethyl Galanthamine
    Synonyms

    N-desmethyl galantamine;
    N-Demethylgalantamine;
    UNII-2BPQ4IVQ21;
    N-Norgalanthamine;
    Norgalantamine;

    CAS No. 41303-74-6
    Molecular Formula C16H19NO3
    Molecular Weight 273.32700
    PSA 50.72000
    LogP 1.83690

    Properties

    Density 1.309g/cm3
    Boiling Point 457.923ºC at 760 mmHg
    Melting Point 142-145ºC
    Flash Point 230.744ºC
    Refractive Index 1.642
    Storage Condition -20ºC Freezer

    Synthesis Route

    (4aS,6R,8aS)-3-methoxy-5,6,9,10-tetrahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol→N-Desmethyl Galanthamine
    (2S,5R)-5-benzyl-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-[2-(4-hydroxyphenyl)ethyl]imidazolidin-4-one→N-Desmethyl Galanthamine
    (4aS,8aS,13R,14aR)-13-benzyl-2-hydroxy-3-methoxy-14-(2,2,2-trifluoroacetyl)-4a,5,9,10,14,14a-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]imidazo[1,2-a]azepine-6,12(13H)-dione→N-Desmethyl Galanthamine

    Precursor

    (2R,11bR)-2-benzyl-8,10-bis(benzyloxy)-9-methoxy-1-(2,2,2-trifluoroacetyl)-1,5,6,11b-tetrahydrospiro[benzo[c]imidazo[1,2-a]azepine-7,1'-cyclohexane]-2',5'-diene-3,4'(2H)-dione
    (4aS,8aS,13R,14aR)-13-benzyl-2-hydroxy-3-methoxy-14-(2,2,2-trifluoroacetyl)-4a,5,9,10,14,14a-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]imidazo[1,2-a]azepine-6,12(13H)-dione
    (4aS,6R,8aS)-3-methoxy-5,6,9,10-tetrahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol
    (2S,5R)-5-benzyl-2-(3,5-dibenzyloxy-4-methoxyphenyl)-3-[2-(4-hydroxyphenyl)ethyl]imidazolidin-4-one

    Downstream Product

    galanthamine

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