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Picture of N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide

N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide

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Origin: China

Cas No: 7411-12-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 100 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 7411-12-3 Formula: C21H23NO6 Molecular Weight: 385.41000

    Description

    Colchicine derivative. A new alkaloid from Gloriosa superba.

    Basic Info

    Chemical Name N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide
    Synonyms

    Formyldescaetylcolchicine,N;
    (S)-7-Formylamino-1,2,3,10-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on;
    N-Formyldesacetylcolchicine;
    N-Formyldeacetylcolchicine;
    COLCHICINE,N-DEACETYL-N-FORMYL;
    N-((S)-1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamid;
    N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-formamide;
    N-formyl-N-deacetylcolchicine;
    N-Desacetyl-N-formyl-colchicin;
    N-deacetyl-N-formylcolchicine;
    Gloriosine;

    CAS No. 7411-12-3
    Molecular Formula C21H23NO6
    Molecular Weight 385.41000
    PSA 83.09000
    LogP 3.50830

    Properties

    Density 1.27g/cm3
    Boiling Point 715.8ºC at 760 mmHg
    Melting Point 264-267ºC
    Flash Point 386.7ºC
    Refractive Index 1.591
    Storage Condition -20ºC Freezer, Under Inert Atmosphere

    Safety Info

    HS Code 2924299090

    Synthesis Route

    formic acid+Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide
    diazomethaneN-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]formamide

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Subcutaneous LDLo - Lowest published lethal dose Rodent - rat 2 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Intravenous LD50 - Lethal dose, 50 percent kill Rodent - rat 4400 ug/kg 1.Behavioral-somnolence (general depressed activity)
    2.Behavioral-muscle weakness
    3.Gastrointestinal-hypermotility, diarrhea
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - mouse 2666 ug/kg 1.Tumorigenic-active as anti-cancer agent

    Precursor

    diazomethane
    Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)-
    formic acid

    Downstream Product

    Benzo[a]heptalen-9(5H)-one,7-amino-6,7-dihydro-1,2,3,10-tetramethoxy-, (7S)-
    1,2,3,10-tetramethoxy-5,6-dihydrobenzo[a]heptalene-7,9-dione

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