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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Pharmaceutical Impurities> N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide
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N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide

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Origin: China

Cas No: 90357-51-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Quick Details

    CAS No.:
    90357-51-0
    Other Names:
    N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide
    MF:
    C12H9F3N2O2
    EINECS No.:
    90357-51-0
    Place of Origin:
    Shanghai, China
    Grade Standard:
    Agriculture Grade, Electron Grade, Food Grade, Industrial Grade, Medicine Grade, Reagent Grade
    Purity:
    99%
    Appearance:
    white powder
    Application:
    medicine
    Brand Name:
    Terppon
    Model Number:
    9
    color:
    white

    Packaging&Delivery

    Lead Time:
    Quantity(Kilograms)1 - 1>1
    Est. Time(days)18To be negotiated

  • Property

    CAS No.: 90357-51-0 Formula: C12H9F3N2O2 Molecular Weight: 270.20700

    Description

    N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyl-2-oxiranecarboxamide, is an intermediate in synthesis of more complex pharmaceutical compounds. It is used in the synthesis of potential impurities of Bicalutamide, which is an oral nonsteroidal, anti-androgen drug used for prostate cancer.

    Basic Info

    Chemical Name N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide
    Synonyms

    N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyl-Oxiranecarboxamide;
    N-(4-cyano-3-trifluoromethylphenyl)-2-methyl-oxiranyl-carboxamide;
    rac-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide;
    1,2-EPOXY-2-METHYL-N-[4-CYANO-3-(TRIFLUOROMETHYL)];
    N-(4-cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide;
    1,2-Epoxy-2-Methyl-N[4-Cyano-3(Trifluoromethyl)-Phenyl]Propanamide;
    1,2-Epoxy-2-methyl-N-(4-cyano-3-trifluoromethyl)-phenyl)propaneamide;
    N-[4-Cyano-3-(triflu;
    N-4-CYANO-3-(TRIFLUOROMETHYL)PHENYLMETHACRYLAMIDE EPOXIDE;
    4-cyano-N-(2,3-epoxy-2-methylpropionyl)-3-trifluoromethylaniline;
    N-[4-Cyano-3-(trifluoroMethyl)phenyl]MethacrylaMid;
    N-(4-cyano-3-trifluoromethyl-phenyl)-2-methyl-2-oxirane-propionamide;
    N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyl-2-oxiranecarboxamide;
    N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyl-oxiranecarboxamine;

    CAS No. 90357-51-0
    Molecular Formula C12H9F3N2O2
    Molecular Weight 270.20700
    PSA 65.42000
    LogP 2.37748

    Properties

    Appearance & Physical State white powder
    Density 1.42 g/cm3
    Boiling Point 436.4ºC at 760 mmHg
    Flash Point 217.7ºC
    Refractive Index 1.526

    Safety Info

    HS Code 2926909090

    Synthesis Route

    hydrogen peroxide+N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-2-Methacrylamide→N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide
    N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-2-Methacrylamide→N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide
    rac-2-methyloxirane-2-carboxylic acid+4-isocyanato-2-(trifluoromethyl)benzonitrile→3-chloro-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide+N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide

    Precursor

    N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-2-Methacrylamide
    2-carbonoperoxoylbenzoic acid
    4-isocyanato-2-(trifluoromethyl)benzonitrile
    rac-2-methyloxirane-2-carboxylic acid

    Downstream Product

    N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-hydroxy-2-methylpropionamide
    Bicalutamide

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