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Home > All categories> Biochemicals and Pharmaceutical Chemicals> Active Pharmaceutical Ingredients (APIs)> Gastrointestinal tract/ metabolism> N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide
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N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide

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Origin: China

Cas No: 100981-43-9

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description

  • Property

    CAS No.: 100981-43-9 Formula: C14H17BrN6O2S3 Molecular Weight: 477.42300

    Description

    Ebrotidine is a H2 receptor antagonist that has shown gastroprotective properties against gastric mucosal damange.

    Basic Info

    Chemical Name N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide
    Synonyms

    FI-3542;
    Ebrotidina [Spanish];
    Ebrotidina;
    Ebrotidine;
    Benzenesulfonamide,N-(((2-(((2-((aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)ethyl)amino)methylene)-4-bromo-,(E);
    Ulsanic;
    Ebrotidinum [Latin];
    Ebrotiding;
    Ebrotidinum;

    CAS No. 100981-43-9
    Molecular Formula C14H17BrN6O2S3
    Molecular Weight 477.42300
    PSA 195.24000
    LogP 4.79570

    Properties

    Density 1.73g/cm3
    Boiling Point 672.3ºC at 760mmHg
    Flash Point 360.4ºC
    Refractive Index 1.739
    Vapor Pressure 6.2E-18mmHg at 25°C

    Safety Info

    HS Code 2942000000

    Synthesis Route

    ethyl 4-bromobenzenesulfonyl formimidate+2-[(2-guanidinothiazol-4-yl)methylthio]ethylamine dihydrochloride→N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide
    ethyl 4-bromobenzenesulfonyl formimidate+2-[4-(2-aminoethylsulfanylmethyl)-1,3-thiazol-2-yl]guanidine→N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide
    4-Bromobenzenesulfonamide→N-(4-bromophenyl)sulfonyl-N'-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]methanimidamide

    Toxicity

    Exposure Route Type of Test Species Observed Dose/Duration Toxic Effects
    Oral LD50 - Lethal dose, 50 percent kill Rodent - rat >8 gm/kg 1.Details of toxic effects not reported other than lethal dose value
    Intraperitoneal LD50 - Lethal dose, 50 percent kill Rodent - rat 316 mg/kg 1.Details of toxic effects not reported other than lethal dose value
    Intravenous LD50 - Lethal dose, 50 percent kill Rodent - rat 100 mg/kg 1.Lungs, Thorax, or Respiration-dyspnea
    2.Kidney, Ureter, Bladder-hematuria

    Precursor

    2-[(2-guanidinothiazol-4-yl)methylthio]ethylamine dihydrochloride
    2-[4-(2-aminoethylsulfanylmethyl)-1,3-thiazol-2-yl]guanidine
    ethyl 4-bromobenzenesulfonyl formimidate
    4-Bromobenzenesulfonamide

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