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N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide

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Origin: China

Cas No: 150683-30-0

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 80 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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Products Specification
Product Description

Property

CAS No.: 150683-30-0 Formula: C26H25ClN2O3 Molecular Weight: 448.94100

Description

It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).

Basic Info

Chemical Name	N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
Synonyms	UNII-21G72T1950; Tolvaptan; Samsca; benzazepine derivative,32;
CAS No.	150683-30-0
Molecular Formula	C26H25ClN2O3
Molecular Weight	448.94100
PSA	69.64000
LogP	5.82110

Properties

Density	1.311 g/cm3
Boiling Point	594.4ºC at 760 mmHg
Flash Point	313.3ºC
Refractive Index	1.663
Vapor Pressure	5.64E-15mmHg at 25°C

Synthesis Route

N-[4-(7-chloro-5-oxo-3,4-dihydro-2H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide→N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
2-methyl-4-nitrobenzoyl chloride→N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
7-Chloro-1,2,3,4-Tetrahydro-Benzo[B]Azepin-5-One→N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide

Precursor

N-[4-(7-chloro-5-oxo-3,4-dihydro-2H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
2-methyl-4-nitrobenzoyl chloride
7-Chloro-1,2,3,4-Tetrahydro-Benzo[B]Azepin-5-One
1-(4-amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-2H-1-benzazepin-5-one

Downstream Product

N-[4-(7-chloro-5-oxo-3,4-dihydro-2H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide

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