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Picture of N-[2-hydroxy-6-[(4-methoxybenzoyl)amino]phenyl]-4-(4-methyl-1,4-diazepan-1-yl)benzamide

N-[2-hydroxy-6-[(4-methoxybenzoyl)amino]phenyl]-4-(4-methyl-1,4-diazepan-1-yl)benzamide

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Origin: China

Cas No: 365462-23-3

Specification: 99%min

Min order Quantity: 1 /kg

Supply Ability: 50 mt/month

Lead time: 7 days for OEM, 3 days for ready goods

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  • Products Specification
  • Product Description
  • Property

    CAS No.: 365462-23-3 Formula: C27H30N4O4 Molecular Weight: 474.55200

    Description

    Darexaban (YM150) is a direct inhibitor of factor Xa created by Astellas Pharma. It is an experimental drug that acts as an anticoagulant and antithrombotic to prevent venous thromboembolism after a major orthopaedic surgery, stroke in patients with atrial fibrillation and possibly ischemic events in acute coronary syndrome. It is used in form of the maleate. The development of darexaban was discontinued in September 2011.

    Basic Info

    Chemical Name N-[2-hydroxy-6-[(4-methoxybenzoyl)amino]phenyl]-4-(4-methyl-1,4-diazepan-1-yl)benzamide
    Synonyms

    Darexaban;
    UNII-KF322K101S;
    Tanexaban;

    CAS No. 365462-23-3
    Molecular Formula C27H30N4O4
    Molecular Weight 474.55200
    PSA 94.14000
    LogP 4.19620

    Synthesis Route

    N-(2-hydroxy-6-nitrophenyl)-4-(4-methyl-1,4-diazepan-1-yl)benzamideN-[2-hydroxy-6-[(4-methoxybenzoyl)amino]phenyl]-4-(4-methyl-1,4-diazepan-1-yl)benzamide
    2-amino-3-nitrophenyl 4-(4-methyl-1,4-diazepan-1-yl)benzoate hydrochlorideN-[2-hydroxy-6-[(4-methoxybenzoyl)amino]phenyl]-4-(4-methyl-1,4-diazepan-1-yl)benzamide
    2-Amino-3-nitrophenolN-[2-hydroxy-6-[(4-methoxybenzoyl)amino]phenyl]-4-(4-methyl-1,4-diazepan-1-yl)benzamide

    Precursor

    2-Amino-3-nitrophenol
    N-(2-amino-6-hydroxyphenyl)-4-(4-methyl-1,4-diazepan-1-yl)benzamide
    4-Methoxybenzoyl chloride
    2-amino-3-nitrophenyl 4-(4-methyl-1,4-diazepan-1-yl)benzoate hydrochloride

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